New conjugates of vinblastine and its derivatives, process for p

Details New conjugates of vinblastine and its derivatives, process for p New conjugates of vinblastine and its derivatives, process for p

1986-12-12

1989-05-09

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

435 68, 435 69, 530362, 530363, 530388, 530391, 530807, 530812, 530828, 424 858, A61K 3944, C07K 1514

Patent

active

048288314

ABSTRACT:
A description is given of conjugates of vinca alkaloid of the indole-dihydroindole type with a protein or a protein fragment, corresponding to the general formula ##STR1## in which R.sub.1 denotes a protein or a protein fragment;

REFERENCES:
patent: 4388305 (1983-06-01), Trouet et al.
patent: 4667030 (1987-05-01), Cullinan
patent: 4675400 (1987-06-01), Cullinan
Selective Cytotoxicity Against Human Tumour Cells by a Vindesine-Monoclonal Antibody Conjugate, by M. J. Embleton et al., Br. J. Cancer (1983) 47, 043-049, pp. 43-49.
Monoclonal Antibodies for Targeted Therapy with Vindesine, by G. F. Rowland et al., B.2 Oncology, vol. 30, pp. 375-379.
Localisation and Toxicity Study of a Vindesine-Anti-CEA Conjugate in Patients with Advanced Cancer, by C. H. J. Ford et al., Br. J. Cancer (1983), 47,035-042, pp. 35-42.
A Vindesine-Anti-CEA Conjugate Cytotoxic for Human Cancer Cells in Vitro, by J. R. Johnson et al., Br. J. Cancer (1981) 44,372, pp. 472-475.
Embleton et al. "Antitumour Reactions of Monoclonal Antibody Against a Human Osteogenic-Sarcoma Cell Line", Br. J. Cancer, vol. 43, pp. 582-587 (1981).
Ritz et al., "A Monoclonal Antibody to Human Acute Lymphoblastic Leukaemia Antigen", Nature, vol. 283, pp. 583-585 (1980).
K. Sikora et al. "Human Monoclonal Antibodies to Lung-Cancer Antigens", Br. J. Cancer, vol. 43, pp. 696-700 (1981).
Ball et al., "Monoclonal Antibodies Reactive with Human Myeloid Leukaemia Cells", Clin. Exp. Immunol., vol. 48, pp. 655-665 (1982).
Masuho, et al. "Interaction of Monoclonal Antibodies with Cell Surface Antigens of Human Ovarian Carcinomas" Cancer Research, vol. 44, pp. 2813-2819 (1984).
Thompson et al., "A Human Breast Tissue-Associated Antigen Detected by a Monoclonal Antibody", J.N.C.I., vol. 70, pp. 409-419 (1983).
Kennett et al., "Hybrid Myelomas Producing Antibodies Against a Human Neuroblastoma Antigen Present on Fetal Brain", Science, vol. 203, pp. 1120-1121 (1979).
Koprowski et al., "Study of Antibodies Against Human Melanoma Produced by Somatic Cell Hybrids" Proc. Natl. Acad. Sci. USA, vol. 75, pp. 3405-3409 (1978).
Thompson et al., "Monoclonal Antibodies to Human Colon and Colorectal Carcinoma", Br. J. Cancer, vol. 47, pp. 595-605 (1983).
Ball, et al., "Monoclonal Antibodies Reactive with Small Cell Carcinoma of the Lung", J.N.C.I., vol. 72, pp. 593-598 (1984).
Conrad, et al., "Structure-Activity Relationships of Dimeric Catharanthus Alkaloids. 2. Experimental Antitumor Activities of N-Substituted Deacetylvinblastine Amide (Vindesine) Sulfates", Jour. of Medicinal Chemistry, vol. 22, pp. 391-400 (1979).
Teale, et al., "Radioimmunoassay of Vinblastine and Vincristine", Br. J. Clin. Pharmac., vol. 4, pp. 169-172 (1977).
Means et al. "Chemical Modification of Proteins", Holden Day Inc., pp. 110-111 (1971).

Affiliated with

Also associated with

Rating

New conjugates of vinblastine and its derivatives, process for p does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New conjugates of vinblastine and its derivatives, process for p, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New conjugates of vinblastine and its derivatives, process for p will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-88838