New conjugates associating, by covalent bond, an enzyme with an

Drug – bio-affecting and body treating compositions – Lymphokine

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424 943, 455177, A61K 39395, A61K 3944, A61K 3748, C12N 1102

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047627077

ABSTRACT:
The present invention relates to new immunoenzymic conjugates resulting from a chemical coupling, by covalent bond, of an antibody or a fragment of antibody, which has retained the capacity of recognizing the selected antigen, with an enzyme capable of producing ammonium ions from natural substrates which are well tolerated in higher animal organisms.
The invention also relates to a process for the preparation of these conjugates and the medicinal associations of said conjugates with an immunotoxin.

REFERENCES:
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patent: 4340535 (1982-07-01), Voisin et al.
patent: 4414148 (1983-11-01), Jansen et al.
patent: 4643895 (1987-02-01), Casellas et al.
King, T. et al., J. Immunol, Methods, vol. 28, pp. 201-210, 1979.
Chemical Abstracts, vol. 70, Abst. No. 1046235, 1969.
Biological Abstracts, vol. 71, Abst. No. 31289, 1980.
Chemical Abstracts, vol. 96, Abst. No. 329792, 1982.
Comprehensive Biochemistry, Florkin, vol. 13, 3d Ed., Enzyme Nomenclature, Elsevier Scientific, 1973.

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