New compounds which are active against the tissue forms of malar

Details New compounds which are active against the tissue forms of malar New compounds which are active against the tissue forms of malar

1989-09-22

1992-05-05

Russel, Jeffrey E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514314, 514895, 530330, 530331, A61K 3147, C07D21538, C07D21540, C07K 502

Patent

active

051109352

ABSTRACT:
The invention relates to new quinoline derivatives containing a free amine group and having antimalarial properties, in particular new primaquine derivatives or their addition salts with acids, and to a method for preparing them.
According to the invention, these new derivatives are represented schematically by the formula:

REFERENCES:
patent: 4703107 (1987-10-01), Monsyny et al.
patent: 4897267 (1990-01-01), Bontemps et al.
J. Med. Chem., vol. 31/1988, pp. 870-874, Philip et al.
J. Med. Chem., vol. 29, 1986, pp. 1765-1769, Hofsteenge et al.
Chem. Abst., vol. 99, #17, 1983, p. 637, #140345k, by Hu et al.
J. Med. Chem., vol. 31/1988, pp. 870-874, Philip et al., "Peptide derv. of primaquine . . . ".
Chem. Ab., vol. 99, #17, 1983, p. 637 #140345k, Hu et al., Peptide derv. of Primaquine.
El-Nagyru, CA 102:25012t, Synthesis of dipeptide derv. and studies of antimicrobial activities (1985).

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