New anti-malarial agents

Details New anti-malarial agents New anti-malarial agents

1974-08-07

1976-04-06

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260279A, 260279R, 260287AR, 260288CE, 260288R, 424257, 424258, C07D21544

Patent

active

039489205

ABSTRACT:
Compounds of the formula ##SPC1##
Wherein A designates that the fused six-membered ring could be either unreduced, partially reduced or totally reduced and wherein R.sup.1 is --N(CH.sub.3).sub.2, --N(C.sub.2 H.sub.5).sub.2, ##EQU1## or --N(CH.sub.2 CH.sub.2 Cl).sub.2 and R.sup.2 is ##SPC2##
And R is an acyl group with 1-5 carbon atoms, and pharmaceutically acceptable salts thereof; processes for their preparation; pharmaceutical preparations containing at least one of these compounds and the use thereof in the treatment of and protection against malaria infection.

REFERENCES:
patent: 2474821 (1949-07-01), Burckhalter
patent: 3075981 (1963-01-01), Surrey
Nabih; Experientia, Vol. 27, p. 1114 (1972).

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