New 8-substituted nucleoside and purine derivatives, the process

Details New 8-substituted nucleoside and purine derivatives, the process New 8-substituted nucleoside and purine derivatives, the process

1985-09-16

1988-09-27

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 27, 536 183, 536120, 544265, 544267, C07H 1920, A61K 3170

Patent

active

047743255

ABSTRACT:
New 8-substituted nucleoside and purine derivatives of the general formula: ##STR1## wherein R represents an amino group or an hydroxy group possibly in the corresponding keto tautomeric form, R.sub.1 is hydrogen or an amino group, R.sub.2 is hydrogen or a .beta.-D-ribofuranosyl radical wherein the primary hydroxy group and/or the two secondary hydroxy groups may be derivatized, R.sub.3 is an optionally substituted aryl or monocyclic heteroaryl radical and, X is --O-- or --S--. The new compounds have antihyperlipaemic activity.

REFERENCES:
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patent: 3391196 (1968-07-01), Earing et al.
patent: 3712885 (1973-01-01), Weimann et al.
patent: 4048307 (1977-09-01), Yokota et al.
patent: 4446313 (1984-05-01), Dix et al.
Chemical Abstracts, vol. 84, 1976, p. 587, Abstract No. 105653c, Columbus, Ohio, U.S. & JP-A-75 15 800 (Dainippon Pharmaceutical Co., Lt.), 07-06-1975.
R. M. Acheson, An Introduction to the Chemistry of Heterocyclic Compounds, Wiley-Interscience, 1967, New York, p. 338.
J. March, Adv. Organic Chemistry, Reaction + Mechanism + Structure, McGraw Hill, New York, 1968, p. 328.

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