New 4'-epi-4'-amino anthracyclines

Details New 4'-epi-4'-amino anthracyclines New 4'-epi-4'-amino anthracyclines

1993-01-06

1995-05-02

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

054120810

ABSTRACT:
Anthracycline glycosides having the general formula 1 and 2: ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, fluorine, hydroxy or amino; R.sub.2 and R.sub.3 represent hydroxy or one of R.sub.2 and R.sub.3 is a hydrogen atom, a nitro or an amino group and the other of R.sub.2 and R.sub.3 is a HYDROXY group, exhibit activity against LoVo and LoVo/Dx in vitro.

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patent: 4987126 (1991-01-01), Bargiotti et al.
Biomedical and Environmental Mass Spec., vol. 13, 1986, John Wiley & Sons Ltd, C. Monneret et al.: "Desorption chemical ionization mass spectrometry of anthracyclines and of trisaccharides related to Aclacinomycin A and arcellomycin", pp. 319-326.

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