Neutrophil chemoattractants

Details Neutrophil chemoattractants Neutrophil chemoattractants

1989-12-22

1993-08-31

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, A61K 3702, C07K 302, C07K 1506

Patent

active

052410498

ABSTRACT:
Substantially pure porcine proteins having chemoattractant activity for neutrophils and methods for preparing the proteins are provided. These proteins are useful within compositions for enhancing neutrophil chemotaxis, such as in promoting the formation of granulation tissue. The proteins may also be used within methods for developing inflammatory and anti-inflammatory agents.

REFERENCES:
Golds et al, "Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor . . . ". Biochem. J. (1989) 259, 585-88.
Gregory et al, "Structure Determination of a Human Lymphocyte Derived Neutrophil Activity Peptide", Biochem. Biophys. Res. Comm. vol. 151, No. 2, 1988, pp. 883-890.
Walz et al, "Purification and Amino Acid Sequencing of NAF . . . ", Biochem. Biophys. Res. Comm. vol. 149, No. 2, 1987, pp. 755-761.
Matsushima et al, "Molecular Cloning of a Human Monocyte-Derived Neutrophil Chemotactic Factor . . . " J. Exp. Med., vol. 167, Jun. 1988, pp. 1883-1893.
Suzuki et al, "Purification and Partial Primary Sequence of a Chemotactic Protein for Polymorphonuclear Leukocytes . . . ", J. Exp. Med. vol. 169, Jun. 1989, pp. 1895-1901.
Schroder et al, "Identification of Different Charged Species of a Human Monocyte Derived Neutrophil Activating peptide (MONA)", Biochem. Biophys. Res. Comm. 152:277-284, 1988.
Wolpe et al, "Identification and characterization of macrophage inflammatory protein 2", Proc. Natl. Acad. Sci. USA 86:612-616, 1989.
Strieter et al., "Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-a, LPS, and IL-.beta.", Science 243:1467-1469, 1989.

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