Neutrophil-activating peptide-2

Details Neutrophil-activating peptide-2 Neutrophil-activating peptide-2

1995-06-06

1998-06-02

Ulm, John

Drug, bio-affecting and body treating compositions

Lymphokine

4241841, 4241981, 514 2, 514 8, 514 12, 514885, 530324, C07K 1452, A61K 3819

Patent

active

057595330

ABSTRACT:
Peptides having the amino acid sequence ##STR1## wherein X is H, Asp-Leu-Tyr-, Ser-Asp-Leu-Tyr- or Asp-Ser-Asp-Leu-Tyr-. The peptide wherein X is H is human neutrophil-activating peptide-2 (hNAP-2) and those wherein X is other than H are natural variants thereof. The peptides have neutrophil-stimulating activity, are structurally related to NAF/NAP-1, .beta.-thromboglobulin, PBP and CTAP-III and may be isolated from leukocytes and platelets and synthesized by standard peptide synthesis processes and recombinant DNA techniques.

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