Surgery – Radioactive substance applied to body for therapy
Patent
1992-12-31
1995-07-18
Kamm, William E.
Surgery
Radioactive substance applied to body for therapy
A61N 500
Patent
active
054336937
ABSTRACT:
Patient treatment rooms are circularly spaced around a nuclear reactor core. Suitable shielding is provided between the rooms and the core, with neutron transmission passageways provided in the shielding from the core to provide space for appropriate collimating equipment. The core is generally cylindrical and multi-regional, with the inner two or three regions containing nuclear fuel, the inner core producing most of the fission neutrons, the first core ring containing a low enrichment fuel, and the third containing thorium or depleted uranium metal or some other heavy metal for inelastic scattering of neutrons and gamma ray absorption. Two moderator rings, each containing a different moderator liquid composition with variable thermal neutron absorbers and gamma ray absorbers, surrounding the multi-regional core. A heavy metal gamma ray shield surrounds the second moderator ring. The arrangement constricts the neutron spectrum in the reactor itself to transmit only epithermal neutrons to the patients, without the typical spectrum shaping filters normally contemplated for use between reactors and treatment subjects.
REFERENCES:
F. S. Wheeler et al., "Reactor Physics Design for An Epithermal Neutron Beam . . .", 1989, pp. 69-71.
Nigg et al., "Conceptual Physics Design of an Epithermal-Neutron Facility . . .".
Neuman et al., "Conceptual Design of A Medical Reactor for Neutron Capture Therapy", Oct. 1990, pp. 77-92.
Mishima, "Investigation of a Nuclear Reactor for Cancer Therapy", 1990 March.
B. J. Allen et al., "Performance of the Currently Available Epithermal Neutron Beam . . . ", 1999, pp. 53-56.
O. K. Harling et al., "Installation and Testing of an Optimized Epithermal Neutron Beam . . .", 1990, pp. 185-199.
Floyd J. Wheeler et al., "Epithermal Neutron Beam Design for Neutron Capture Therapy . . .", Oct. 1990, pp. 106-117.
David W. Nigg et al., "Demonstration of Three-Dimensional Determinstic Radiation Transport . . .", Jan./Feb. 1991, pp. 43-53.
Ref. 1 "Boron Neutron Capture Therapy and Radiation Synovectomy Research at the Massachusetts Insitute of Technology Research Reactor", Nuclear Science and Engineering, Otto K. Harling et al., vol. 110, pp. 330-348, Apr. 1992.
Ref. 2 "Possible Use of Cold Neutrons for Boron Neutron Capture Therapy", Nuclear Science and Engineering, M. Papaspyrou and L. E. Feinendegen, vol. 110, pp. 349-354, Apr. 1992.
"Development and Deployment of a Revolutionary Brain Tumor Treatment" Boron Neutron Cancer Therapy-University Consortium, Inc.
Excerpt from the Oct. 22, 1993 Conference Report 103-305 to House Resolution 2445 in Congress (referring to "the Department's Boron Neutron Capture Therapy" (BNCT)* Program and the BNCT-University Consortium).
"Clinical Results of Boron Neutron Capture Therapy", Progress in Neutron Capture Therapy for Cancer, Edited by B. J. Allen et al., Plenum Press, New York 1992 pp. 561-568.
Kamm William E.
Lacyk John P.
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