Neutralizing monoclonal antibody 0.5.beta. which binds an epitop

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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53038835, 435 7821, C12N 520, C07K 1608, G01N 3353

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active

058277234

ABSTRACT:
The present invention relates to monoclonal antibody 0.5.beta. which binds to an epitope located within the region of amino acids 308-331 of HTLVIIIB gp120 and is capable of substantially neutralising the activity of human immunodeficiency viruses, to a hybridoma which produces the 0.5.beta. antibody, to processes for preparing them and to compositions containing an effective amount of the antibody.

REFERENCES:
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Bolognesi et al. J. Acquired Immune Deficiency Syndromes; 3:390-394, 1990.
Skinner et al. AIDS Research and Human Retroviruses 4:187-197, 1988.
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Devash et al. PNAS 87:3445-3449, 1990.
Matsushita J Virology 62:2107-2114, 1988.
Thomas et al. AIDS 2:25-29 1988.
Linsley et al. J Virology 62:3695-3702 1988.
Skinner et al. J Virology 62:4195-4200 1988.

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