Neutralizing high affinity human monoclonal antibodies specific

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

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4241471, 4243913, 4351723, 536 2353, A61K 39395, A61K 3942, C12N 1500, C07H 2104

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active

058661255

ABSTRACT:
A method of obtaining high affinity human monoclonal antibodies having a Kd of .ltoreq.2.times.10.sup.-9 molar in SCID mice is provided.

REFERENCES:
patent: 4517304 (1985-05-01), Stott et al.
patent: 4659563 (1987-04-01), Dobkin
patent: 4717766 (1988-01-01), Dobkin
patent: 4760026 (1988-07-01), Lennox et al.
patent: 4800078 (1989-01-01), Prince et al.
patent: 4853326 (1989-08-01), Quash et al.
patent: 5071758 (1991-12-01), Stott et al.
patent: 5137804 (1992-08-01), Greene et al.
patent: 5149650 (1992-09-01), Wertz et al.
patent: 5183657 (1993-02-01), Buurman
patent: 5194595 (1993-03-01), Wathen
patent: 5219996 (1993-06-01), Bodmer et al.
patent: 5223254 (1993-06-01), Paradiso et al.
patent: 5240694 (1993-08-01), Gwaltney, Jr.
patent: 5271927 (1993-12-01), Parker et al.
patent: 5279935 (1994-01-01), Nycz
patent: 5288630 (1994-02-01), Wathen
patent: 5290540 (1994-03-01), Prince et al.
patent: 5332567 (1994-07-01), Goldenberg
patent: 5332805 (1994-07-01), Carey et al.
patent: 5340926 (1994-08-01), Lowe et al.
patent: 5354554 (1994-10-01), Rhind
patent: 5391478 (1995-02-01), Greene et al.
patent: 5412077 (1995-05-01), Siber et al.
patent: 5418136 (1995-05-01), Miller et al.
patent: 5422097 (1995-06-01), Gwaltney, Jr.
patent: 5424189 (1995-06-01), Oberst et al.
patent: 5468606 (1995-11-01), Bogart et al.
patent: 5470736 (1995-11-01), Verma et al.
patent: 5484893 (1996-01-01), Parker et al.
patent: 5506209 (1996-04-01), Mukerji et al.
patent: 5518725 (1996-05-01), Daynes et al.
patent: 5530102 (1996-06-01), Gristina et al.
patent: 5534411 (1996-07-01), Weltzin
patent: 5538733 (1996-07-01), Emery et al.
patent: 5538952 (1996-07-01), Mukerji et al.
Trudel et al., Synthetic peptides corresponding to the F protein of RSV stimulate murine B and T cells but fail to confer protection, Arch Virol 117:59-71, see connecting paragraphs, pp. 61-62 and 64-65, 1991.
Zhang et al., Soluble Factor-Independent Stimulation of Human B Cell Response by Mouse Thymoma Cells, J. Immunol., 144, 2955-2960, 1990.
Mosier et al., Transfer of a functional human immune system to mice with severe combined immunodeficiency, Nature, 335: 256-259, 1988.
McCune et al., The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function, Science, 241, 1632-1639, 1988.
Gorny et al, Generation of human monoclonal antibodies to human immunodeficiency virus, PNAS, 86: 1624-1628, see Abstract, 1989.
Kozbor et al., Requirements for the establishment of high-titered human monoclonal antibodies against tetnus toxoid using the Epstein-Barr virus technique, J. Immunol., 127, 1275-1280, see Abstract, 1981.
Paul W., E., 1993, Fundamental Immunology, p. 242.
Seaver, 1994, Genetic Engineering News, vol. 14(14), pp.10+21.

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