Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2004-11-09
2008-08-05
Gambel, Phillip (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388220, C530S388240, C530S387100
Reexamination Certificate
active
07408043
ABSTRACT:
The neutralizing antibody against HGF binding to the inventive neutralizable epitope of HGF is capable of neutralizing HGF as a single agent, and can be effectively used for preventing and treating intractable diseases and cancers that are caused by binding of HGF to its receptor Met.
REFERENCES:
Cao,B et al. “Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antiturmor activity in animal models” PNAS Jun. 2001, vol. 98(13):7443-8, See entire document.
Lederman et al. Molecular Immunology 28: 1171-1181, 1991.
Li et al. PNAS 77: 3211-3214, 1980.
Bost et al. (Immunological Investigations, 1988, 17:577-586.
Bendayan The Journal of Histochemistry and Cytochemistry, 1995, 43:881-886.
Burr, A.W. et al., “Anti-hepatocyte Growth Factor Antibody Inhibits Hepatocyte Proliferation During Liver Regeneration,” J. of Pathology, vol. 185: 298-302 (1998).
Di Nicola, M. et al. “Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular on nonspecific mitogenic stimula,” Blood, vol. 99, No. 10, May 15, 2002, 3838-3843.
Tabor, K. et al., “Monoclonal Antibodies (MABS) to the NK1 Region of Human Hepatocyte Growth Factor (HGF) Block HGF Activity, ” J. Cellular Biochemcistry, No. 18, part A, Jan. 16, 1994, p. 288.
Zaccolo M., et al., “Dimidiation of Fab fragments enables ready screening of phage antobodies that affect hepatocyte growth factor/scatter factor activity on target cells,” Eur. J. Immunol., vol. 27, No. 3, 1997, 618-623.
Hu, C., et al., “Cloning and sequencing of variable region genes of Hab25 McAb agains hepatocellular carcinoma,” Database Medline, XP-002447481, Database accession No. NLM10488420, June 1999.
Schmidt, N.O. et al., “Levels of Vascula Endothelial Growth Factor, Hepatocyte Growth Factor/Scatter Factor and Basic Fibroblast Growth Factor in Human Gliomas and Their Relation to Angiogenesis,” Int. J. Cancer, 84, 10-18 (1999).
Lamszuz, K., et al., “Scatter Factor Promotes Motility of Human Glioma and Neuromicrovascular Endothelial Cells,” Int. J. Cancer, 75, 19-28 (1998).
Chung Junho
Hur Youngmi
Gambel Phillip
National Cancer Center
Sughrue & Mion, PLLC
Wen Sharon
LandOfFree
Neutralizing antibody against HGF does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Neutralizing antibody against HGF, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neutralizing antibody against HGF will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4019392