Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-12-25
2007-12-25
Spector, Lorraine (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S388220, C530S388850, C530S387300, C530S388230, C424S130100, C424S133100, C424S141100
Reexamination Certificate
active
11009939
ABSTRACT:
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.
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Kawasaki et al. 2003. Jnl of Immunology. 170:413-420.
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Winter et al. 1985. EMBO J. 4:2861-2867) teach a sequence (amino acids 19-134.
Elrifi Ivor R.
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
Novimmune SA
Shafer Shulamith H.
Spector Lorraine
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