Neutralizing antibodies against HIV infection

Details Neutralizing antibodies against HIV infection Neutralizing antibodies against HIV infection

1998-05-11

2000-02-29

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 4353391, 435334, 435974, 435975, 5303881, 53038822, 53038835, 5303894, C12Q 170

Patent

active

060307722

ABSTRACT:
Neutralizing antibodies against HIV infection are provided. The antibodies are reactive with cryptic epitopes on gp120 and/or CD4 induced by the formation of immunogenic complexes comprising gp120 covalently bonded to CD4 or to succinyl concanvalin A.

REFERENCES:
Watanabe, M., Chen, Z.W., Tsubota, H., Lord, C.I., Levine, C.G. and Letvin, N.L. Soluble human CD4 elicits an antibody response in rhesus monkeys that inhibits simian immunodeficiency virus replication. Proc. Natl. Acad. Sci. USA 88:120-124, 1991.
Sattentau, Q.J. and Moore, J.P. Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding. J. Exp. Med. 174:407-415, 1991.
Robert-Guroff, M. HIV-neutralizing antibodies: epitope identification and significance for future vaccine. Int. Rev. Immunol. 7:15-30, 1990.
Putney, S. How antibodies block HIV infection: paths to an AIDS vaccine. TIBS 17:1991-196, 1992.
Putney, S.D., Rusche, J., Javaherian, K., Matthews, T. and Bolognesi, D. Structural and functional features of the HIV envelope glycoprotein and considerations for vaccine development. Biotechnology 14:81-110, 1990.
Allan, J.S., Coligan, J.E., Barin, F., McLane, M.F., Sodroski, J.G., Rosen, C.A., Haseltine, W.A., Lee, T.H. and Essex, M. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III. Science 228:1091-1094, 1985.
Veronese, F.D., DeVico, A.L., Copeland, T.D., Oroszlan, S., Gallo, R.C. and Sarngadharan, M.G. Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene. Science 229:1402-1405, 1985.
Ohno, T., Terada, M., Yoneda, Y., Shea, K.W., Chambers, R.F., Stroka, D.M., Nakamura, M. and Kufe, D.W. A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120. Proc. Natl. Acad. Sci. USA 88:10726-10729, 1991.
Masuda, T., Matsushita, S., Kuroda, M.J., Kannagi, M., Takatsuki, K. and Harada, S. Generation of neutralization-resistant HIV-1 in vitro due to amino acid interchanges of third hypervariable env region. J. Immunol. 145:3240-3246, 1990.
Ho, D.D., Kaplan, J.C., Rackauskas, I.E. and Gurney, M.E. Second conserved domain of gp120 is important for HIV infectivity and antibody neutralization. Science 239:1021-1023, 1988.
Sun, N.C., Ho, D.D., Sun, C.R., Liou, R.S., Gordon, W., Fung, M.S., Li, X.L., Ting, R.C., Lee, T.H., Chang, N.T. and Chang, T.W. Generation and characterization of monoclonal antibodies to the putative CD4-binding domain of human immunodeficiency virus type 1 gp120. J. Virol. 63:3579-3585, 1989.
Chanh, T.C., Dreesman, G.R., Kanda, P., Linette, G.P., Sparrow, J.T., Ho, D.D. and Kennedy, R.C. Induction of anti-HIV neutralizing antibodies by synthetic peptides. EMBO J. 5:3065-3071, 1986.
Ho, D.D., McKeating, J.A., Li, X.L., Moudgil, T., Daar, E.S., Sun, N.C. and Robinson, J.E. Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody. J. Virol. 65:489-493, 1991.
Dalgleish, A.G., Beverley, P.C., Clapham, P.R., Crawford, D.H., Greaves, M.F. and Weiss, R.A. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763-767, 1984.
McDougal, J.S., Kennedy, M.S., Sligh, J.M., Cort, S.P., Mawle, A. and Nicholson, J.K. Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule. Science 231:382-385, 1986.
Thali, M., Furman, C., Ho, D.D., Robinson, J., Tilley, S., Pinter, A., and Sodroski, J. Discontinuous, conserved neutralization of epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein. J. Virol. 66:5635-5641, 1992.
Moore, J.P., McKeating, J.A., Weiss, R.A. and Sattentau, Q.J. Dissociation of gp120 from HIV-1 virions induced by soluble CD4. Science 250:1139-1142, 1990.
Hart, T.K., Kirsh, R., Ellens, H., Sweet, R.W., Lambert, D.M., Petteway, S.R.,Jr., Leary, J. and Bugelski, P.J. Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120. Proc. Natl. Acad. Sci. USA 88:2189-2193, 1991.
Mizuochi, T., Matthews, T.J., Kato, M., Hamako, J., Titani, K., Solomon, J. and Feizi, T. Diversity of oligosaccharide structures on the envelope glycoprotein gp 120 of human immunodeficiency virus 1 from the lymphoblastoid cell line H9. Presence of complex-type oligosaccharides with bisecting N-acetylglucosamine residues. J. Biol. Chem. 265:8519-8524, 1990.
Geyer, H., Holschbach, C., Hunsmann, G. and Schneider, J. Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120. J. Biol. Chem. 263:11760-11767, 1988.
Larkin, M., Childs, R.A., Matthews, T.J., Thiel, S., Mizuochi, T., Lawson, A.M., Savill, J.S., Haslett, C., Diaz, R. and Feizi, T. Oligosaccharide-mediated interactions of the envelope glycoprotein gp120 of HIV-1 that are independent of CD4 recognition. AIDS 3:793-798, 1989.
Ezekowitz, R.A., Kuhlman, M., Groopman, J.E. and Byrn, R.A. A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus. J. Exp. Med. 169:185-196, 1989.
Schooley, R.T., Merigan, T.C., Guat, P., Hirsch, M.S., Holodniy, M., Flynn, T., Liu, S., Byington, R.E., Henochowicz, S., Gubish, E. and et al, Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase I-II escalating dosage trial. Ann. Intern. Med. 112:247-253, 1990.
Watanabe, M., Boyson, J.E., Lord, C.I. and Letvin, N.L. Chimpanzees immunized with recombinant soluble CD4 develop anti- self CD4 antibody responses with anti-human immunodeficiency virus activity. Proc. Natl. Acad. Sci. USA 89:5103-5107, 1992.
Kahn, J.O., Allan, J.D., Hodges, T.L., Kaplan, L.D., Arri, C.J., Fitch, H.F., Izu, A.E., Mordenti, J., Sherwin, J.E., Groopman, J.E. and et al, The safety and pharmacokinetics of recombinant soluble CD4 (rCD4) in subjects with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase 1 study. Ann. Intern. Med. 112:254-261, 1990.
Grewe, C., Beck, A., and Gelderblom, H.R. HIV: Early virus-cell interactions. J. Acq. Immune Def. Synd. 3:965-974, 1990.
Robinson, W.E., Jr., Montefiori, D.C. and Mitchell, W.M. Evidence that mannos yl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis. AIDS Res. Hum. Retroviruses 3:265-282, 1987.
Gattegno, L., Ramdani, A., Jouault, T., Saffar, L. and Gluckman, J.C. Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1). AIDS Res. Hum. Retroviruses 8:27-37, 1992.
Pal, R., Veronese, F.D., Nair, B.C., Rahman, R., Hoke, G., Mumbauer, S.W., and Sarngadharan, M.G. Characterization of a neutralizing monoclonal antibody to the external glycoprotein of HIV-1. Intervirology, in press.
Veronese, F.D., Rahman, R., Pal, R., Boyer, C., Romano, J., Kalyanaraman, V.S., Nair, B.C., Gallo, R.C. and Sarngadharan, M.G. Delineation of immunoreactive, conserved regions in the external glycoprotein of the human immunodeficiency virus type 1. AIDS Res. Human Retroviruses 8:1125-1132, 1992.
Celada, F., Cambiaggi, C., Maccari, J., Burastero, S., Gregory, T., Patzer, E., Porter, J., McDanal, C. and Matthews, T. Antibody Raised against Soluble CD4-rgp120 complex recognizes the CD4 moiety and blocks membrane fusion without inhibiting CD4-gp120 binding. J. Exp. Med., 172:1143-1150, 1990.
B.F. Haynes, Science, 260:1279-1286, May 28, 1993.
W.G. Robey et al., Proc. Natl. Acad. Sci. USA, 83:7023-7027, Sep. 1986.
S.M. Chamov et al., Journal of Biological Chemistry, 267(22):15916-15922, 1992.
J. Cohen, Science, 262:980-981, Nov. 12, 1993.
Q.J. Sattentau et al., J. Exp. Med., 174:407-415, Aug. 1991.
C. Kang et al., FASEB Journal, 8:5:Abstract 5567, Apr. 1994.
J.M. Gershoni et al., FASEB Journal, 7:12:1185-1187, Sep. 1993.
R. Pal et al., Virology, 194:833-837 (1993).
Edelman et al., International Review of Immunology, 7:1:51-66, 1990.

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