Neutral sphingomyelinase

Details Neutral sphingomyelinase Neutral sphingomyelinase

2000-02-11

2004-05-25

Nolan, Patrick J. (Department: 1644)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Reexamination Certificate

active

06740512

ABSTRACT:

The present invention relates to nucleic acids coding for eukaryotic neutral sphingomyelinase, and applications thereof.
Sphingomyelin is an essential component of plasma membranes. Degradation of sphingomyelin gives a number of substances having potential second messenger properties, e.g., ceramide, sphingosine, sphingosine-1-phosphate. Two sphingomyelin-cleaving enzymatic activities are known, namely that of lysosomal acid sphingomyelinase, and that of plasma-bound neutral sphingomyelinase.
Bacterial neutral sphingomyelinase is a secreted soluble protein.


REFERENCES:
patent: 5919687 (1999-07-01), Chatterjee et al.
patent: WO 9828445 (1998-07-01), None
Chatterjee S. & Ghosh N.: “Neutral sphingomyelinase from human urine” J. Biol. Chem., vol. 264, No. 21 (Jul. 25, 1999), pp. 12554-12561.
Kostellow A. et al.: “Reduction in Extracellular MG2+ Induces Sphingomyelinase, Elevates Ceramide and Releases NF-KB in Aortic Smooth Muscle Cells”, FASEB Journal, vol. 10, No. 6 (Apr. 30, 1996), p. A1253.
Cai Z. et al.: Alteration of the sphingomyelin/ceramide pathway is associated with resistance of the human breast carcinoma MCF7 cells to Tumor Necrosis Factor alpha-mediated cytotoxicity, J. Biol. Chem., vol. 272, No. 11 (Mar. 14, 1997).
Database Genbank, Accession No. AA412649 (May 18, 1997), Hillier et al.: “H. sapiens cDNA clone Image 730457—EST.”.
Tomiuk S. et al.: “Cloned mammalian neutral sphingomyelinase: functions in sphyngolipid signaling?”, Prc. Natl. Acad. Sci. USA, vol. 95, No. 7 (Mar. 31, 1998), pp. 3638-3643.

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