Neutral endopeptidase (NEP) and human soluble endopeptidase...

Details Neutral endopeptidase (NEP) and human soluble endopeptidase... Neutral endopeptidase (NEP) and human soluble endopeptidase...

2007-06-19

2007-06-19

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S212070

Reexamination Certificate

active

11030043

ABSTRACT:
The invention relates to a novel use of known benzazepine, benzoxazepine, benzo-thiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders.The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formulae (1):wherein the symbols have the meanings as given above in the description.

REFERENCES:
patent: 5677297 (1997-10-01), Waldeck et al.
patent: 5952327 (1999-09-01), Waldeck et al.
patent: 2002/0013307 (2002-01-01), Lapuerta et al.
patent: WO 02/094176 (2002-11-01), None
patent: WO 2004/082637 (2004-09-01), None
Tabrizchi, R., “Current Opinion in Investigational Drugs,” Pharmapress, 4(3):329-332 (2003).

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