Neutral-cationic lipid for nucleic acid and drug delivery

Details Neutral-cationic lipid for nucleic acid and drug delivery Neutral-cationic lipid for nucleic acid and drug delivery

2005-12-13

2005-12-13

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S001210, C424S009321, C424S009510, C424S417000, C428S402200

Reexamination Certificate

active

06974589

ABSTRACT:
A lipid represented by the formula:wherein each of R1and R2is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting of (i) —X—(C═O)—Y—, (ii) —X—(C═O)—, and (iii) —X—CH2—, wherein X and Y are independently selected from oxygen, NH, and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

REFERENCES:
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5395619 (1995-03-01), Zalipsky et al.
patent: 5631018 (1997-05-01), Zalipsky et al.
patent: 5891468 (1999-04-01), Martin et al.
patent: 5965434 (1999-10-01), Wolff et al.
patent: 6056973 (2000-05-01), Allen
patent: WO97/00241 (1997-01-01), None
patent: WO97/07784 (1997-03-01), None
patent: WO00/30444 (2000-06-01), None
patent: WO01/26625 (2001-04-01), None
Conner et al., “,” Proc. Nat'l. Acad. Sci. (USA), p. 1715, (Jun. 28, 1984).
Chu and Szoka, “J. Liposome Res.,” vol. 4 (No. 1), p. 361, (Jun. 28, 1994).
Szoke et al., “,” Ann. Rev. Biophys. Bioeng., p. 467, (Jun. 28, 1980).
Zalipsky, S., “Stealth Liposomes, Chapter 9,” CRC Press, (Jun. 28, 1995).
Allen, T.M. et al., “,” Biochemica et Biophysica Acta, p. 99-108, (Jun. 28, 1995).
Zalipsky, S., “,” Bioconjugate Chem., vol. 4 (No. 4), p. 296-299, (Jun. 28, 1993).
Zalipsky, S. et al., “,” FEB Lett., p. 71-74, (Jun. 28, 1994).
Zalipsky, S. et al., “,” Bioconjugate Chem., p. 705-708, (Jun. 28, 1995).
Martin, F. J., “Specialized Drug Del. Systems-Manuf. & Prod. Tech.,” p. 267-316, (Jun. 28, 1990).
Xu and Szoka, “,” Biochemistry, p. 5616-5623, (Jun. 28, 1996).

Affiliated with

Also associated with

Rating

Neutral-cationic lipid for nucleic acid and drug delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neutral-cationic lipid for nucleic acid and drug delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neutral-cationic lipid for nucleic acid and drug delivery will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3514337