Neurturin receptor

Details Neurturin receptor Neurturin receptor

1997-10-24

2000-02-15

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4353201, 435325, 536 231, 536 235, C12P 2106, C12N 1500, C07H 2102, C07H 2104

Patent

active

060251573

ABSTRACT:
NTNR.alpha., NTNR.alpha. extracellular domain (ECD), NTNR.alpha. variants, chimeric NTNR.alpha. (e.g., NTNR.alpha. immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR.alpha.-ligands, for example NTN, by providing NTNR.alpha. to the cell.

REFERENCES:
Hirano, A., "Cytopathology of Amyotrophic Lateral Sclerosis" Advanced in Neurology: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases,Lewis P. Rowland, Raven Press, Ltd., Chapter 8, vol. 56:91-101 (1991).
Hirsch et al., "Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease" Nature334:345-348 (1988).
Hornykiewicz, O., "Neurochemical Pathology and the Etiology of Parkinson's Disease: Basic Facts and Hypothetical Possibilities"Mt. Sinai J. Med.55:11-20 (1988).
Ikeda et al., "Specific expression of the ret proto-oncogene in human neuroblastoma cell lines" Oncogene5:1291-1296 (1990).
Jing et al., "GDNF-Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-.alpha., a Novel Receptor for GDNF" Cell85:1113-1124 (1996).
Jing et al., "GFR.alpha.-2 and GFR.alpha.-3 Are Two New Receptors for Ligands of the GDNF Family" Journal of Biological Chemistry272(52) :33111-33117 (Dec. 26, 1997).
Kaisho et al., "Cloning and expression of a cDNA encoding a novel human neurotrophic factor" FEBS Letters266(1,2) : 187-191 (Jun. 1990).
Kearns et al., "GNDF protects nigral dopamine neurons against 6-hydroxydopamine in vivo" Brain Research672:104-111 (1995).
Klein et al., "A GPI-Linked protein that interacts with Ret to form a candidate neurturin receptor" Nature387 (6634) :717-721 (Jun. 12, 1997).
Koke et al., "High-Level Expression in Escherichia coliand Rapid Purification of Phosphatidylinositol-Specific Phospholipase C from Bacillus cereusand Bacillus thuringiensis "Prot. Express. Purification2:51-58 (1991).
Kotzbauer et al., "Neurturin, a relative of glial-cell-line-derived neurotrophic factor" Nature384:467-470 (1996).
Lai et al., "An Extended Family of Protein-Tyrosine Kinase Genes Differentially Expressed in the Vertebrate Nervous System"Neuron6:691-704 (May 1991).
Lee et al., "Glycosyl-Phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin" Proc. Natl. Acad. Sci. USA90:9930-9934 (1993).
Leibrock et al., "Molecular Cloning and Expression of Brain-derived Neurotrophic Factor" Nature341:149-152 (Sep. 14, 1989).
Lin et al., "GDNF : A Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons" Science260:1130-1132 (1993).
Lindsay and Yancopoulos, "GDNF in a Bind with Known Orphan: Accessory Implicated in New Twist" Neuron17:571-574 (1996).
Maisonpierre et al., "Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression" Oncogene8:3277-3288 (1993).
Maisonpierre et al., "Neurotrophin-3: A Neurotrophic Factor Related to NGF and BDNF" Science274:1446-1451 (Mar. 23, 1990).
Marcyniuk et al., "The Topography of Cell Loss from Locus Caeruleus in Alzheimer's Disease" J. Neurol. Sci.76:335-345 (1986).
Micanovic et al., "Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase" Proc. Natl. Acad. Sci. USA87:157-161 (1990).
Andres et al., "Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis" Oncogene(erratum) 9:2431 (1994).
Andres et al., "Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carinogenesis" Oncogene9:1461-1467 (1994).
Arenas et al., "GDNF Prevents Degeneration and Promotes the Phenotype of Brain Noradrenergic Neurons in Vivo" Neuron15:1465-1473 (1995).
Baloh et al., "TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret" Neuron18(5) :793-802 (May 1997).
Beck et al., "Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain" Nature373:339-341 (1995).
Bennett et al., "Cloning and Characterization of HTK, a Novel Transmembrane Tyrosine Kinase of the EPH Subfamily" Journal of Biological Chemistry269(19):14211-14218 (1994).
Berkemeier et al., "Neurotrophin-5: A Novel Neurotrophic Factor That Activates trk and trkB" Neuron7:857-866 (Nov. 1991).
Buj-Bello et al., "GDHF Is an Age-Specific Survival Factor for Sensory and Autonomic Neurons" Neuron15:821-828 (1995).
Buj-Bello et al., "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase" Nature387(6634):721-724 (Jun. 12, 1997).
Cash et al., "Parkinson's disease and dementia: Norepinephrine and dopamine in locus ceruleus" Neurology37:42-46 (1987).
Chan-Palay et al., "Alterations in Catecholamine Neurons of the Locus Coeruleus in Senile Dementia of the Alzheimer Type and in Parkinson's Disease With and Without Dementia and Depression" The Journal of Comparative Neurology287:373-392 (1989).
Davis et al., "Released form of CNTF receptor .alpha. component as a soluble mediator of CNTF responses"Science259:1736-1739 (1993).
Durbec et al., "GDNF signalling through the Ret receptor tyrosine kinase" Nature381:789-793 (1996).
Hefti, F., "Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Fimbrial Transections" J. of Neuroscience6(8) :2155-2162 (Aug. 1986).
Henderson et al., "GDNF: A Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle" Science266:1062-1064 (1994).
Heumann, R., "Regulation of the Synthesis of Nerve Growth Factor" J. Exp. Biol.132:133-150 (1987).
Hillier, L. et al., "the WashU-Merck EST Project" (Accession No. R02249) (1995).
Moore et al., "Renal and neuronal abormalities in mice lacking GDNF" Nature382:76-79 (1996).
Moran et al., "Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site" Journal of Biological Chemistry266(2) :1250-1257 (Jan. 15, 1991).
Oppenheim et al., "Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF" Nature373:344-346 (1995).
Pasquale et al., "Identification of a Develpomentally Regulated Protein-Tyrosine Kinase by using anti-phosphotyrosine Antibodies to Screen a cDNA Expression Library" Proc. Natl. Acad Sci. USA86:5449-5453 (1989).
Pasquale, E., "Identification of chiken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family" Cell Regulation2:523-534 (1991).
Pichel et al., "Defects in enteric innervation and kidney development in mice lacking GDNF" Nature382;73-76 (1996).
Poulsen et al., "TGF.beta.2 and TGF.beta.3 are potent survival factors for midbrain dopaminergic neurons" Neuron13 (5) :1245-1252 (Nov. 1994).
Pugin et al., "Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopoplysaccharide-binding protein and soluble CD14" Proc. Natl. Acad. Sci. USA90:2744-2748 (1993).
Rhee et al., "Studies of Inositol Phospholipid-Specific Phospholipase C" Science244:546-550 (1989).
Rosenthal et al., "Primary Structure and Biological Activity of a Novel Human Neurotrophic Factor" Neuron4:767-773 (May 1990).
Sajjadi et al., "Identification of a new eph-related receptor tyrosine kinase from mouse and chicken that is developmentally regulated and ecodes at least two forms of the receptor" New Biol.3 (8):769-778 (1991).
Sanchez et al., "Renal agenesis and the absence of enteric neurons in mice lacking GDNF" Nature382:70-73 (1196).
Sanicola et al., "Glial cell l-ne-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins" Proc. Natl. Acad. Sci. USA94(12):6238-6243 (Jun. 10, 1997).
Shukla, S., "Phosphatidylinositol Specific Phospholipases C" Life. Sci.30:1323-1335 (1982).
Stahl et al., "The Alphas, Betas, and Kinases of Cytokine Receptor Complexes" Cell74:587-590 (Aug. 27, 1993

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