Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-12-30
1998-12-01
Fox, David T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 691, 4351723, 435325, 536 235, A61K 4800, C12N 1511, C12N 1585
Patent
active
058439145
ABSTRACT:
A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the respective cDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors is also disclosed. In addition, methods for treating degenerative conditions using neurturin, methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.
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Johnson, Jr. Eugene M.
Kotzbauer Paul T.
Lampe Patricia A.
Milbrandt Jeffrey D.
Fox David T.
Nelson Amy J.
Washington University
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