Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-12-31
2000-07-18
Hutzell, Paula
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, C07K 1400, C07K 14435, C07K 14475
Patent
active
060907789
ABSTRACT:
A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the respective cDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors is also disclosed. In addition, methods for treating degenerative conditions using neurturin, methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.
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Johnson, Jr. Eugene M.
Kotzbauer Paul T.
Lampe Patricia A.
Milbrandt Jeffrey D.
Hutzell Paula
Pak Michael D.
Washington University
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