Neurotrophin-3-deficient embryonic stem cells and mice and their

Details Neurotrophin-3-deficient embryonic stem cells and mice and their Neurotrophin-3-deficient embryonic stem cells and mice and their

1994-06-29

1997-04-29

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424 92, 4351723, A61K 4900, C12N 1500, C12N 1506, G01N 3100

Patent

active

056251238

ABSTRACT:
The present invention provides mouse embryonic stem cells and homozygous mutant mice carrying disruptions in the neurotrophin-3 (NT-3) gene generated by homologous recombination which results in the insertion of a reporter gene or a drug-resistance gene into an exon of the neurotrophin-3 gene. The mice harboring such homozygous mutations have a reduced number of sensory neurons compared with the number of sensory neurons present in a mouse lacking such mutations. These mice may be used to screen for substances that enhance the transcriptional activity of the NT-3 gene.

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