Neurotrophic factors having altered receptor binding specificiti

Details Neurotrophic factors having altered receptor binding specificiti Neurotrophic factors having altered receptor binding specificiti

1994-09-02

1998-01-06

Allen, Marianne P.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Hormones, e.g., prolactin, thymosin, growth factors, etc.

530350, C07K 14475

Patent

active

057056170

ABSTRACT:
A method of altering the receptor binding properties and the stability of neurotrophic factors is set forth. Mutant neurotrophic factors having altered receptor binding specificities are described. Specific embodiments include neurotrophic factors that bind trk receptors but do not bind to the low affinity NGF receptor.

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