Neurotrophic factor

Details Neurotrophic factor Neurotrophic factor

1994-01-21

1995-08-15

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

4352403, 43524031, A01N 102, A61K 3818, C12N 506

Patent

active

054419379

ABSTRACT:
Novel neurotrophic factor compositions are provided, obtained from lung tissue. The factors are found to be active on parasympathetic ganglion neurons enhancing acetylcholine activity. The compositions find use in the treatment of a number of eye disorders.

REFERENCES:
patent: 4923696 (1990-05-01), Appel et al.
patent: 4997929 (1991-03-01), Collins et al.
patent: 5011914 (1991-04-01), Collins et al.
patent: 5068224 (1991-11-01), Fryklund et al.
patent: 5135956 (1992-08-01), Borg et al.
patent: 5166317 (1992-11-01), Wallace et al.
Nature, vol. 332, issued 24 Mar. 1988, Anderson et al, "Basic fibroblast growth factor prevents death . . . ", pp. 360-361.
PNAS, vol. 90, issued Mar. 1993, Clatterbuck et al, "Ciliary neurotrophic factor prevents retrograde . . . ", pp. 2222-2226.
PNAS USA, vol. 89, issued Dec. 1992, Altar et al, "Brain-derived neurotrophic factor augments . . . ", pp. 11347-11351.
Nature, vol. 360, issued 24/31 Dec. 1992, Oppenheim et al, "Brain-derived neurotrophic factor rescues . . . ", pp. 755-757.
PNAS USA, vol. 89, issued Dec. 1992, La Vail et al, "Multiple growth factors cytokines . . . ", pp. 11249-11253.
Investigative Ophthalmology & Visual Science, vol. 34, No. 12, issued Nov. 1993, Siliprandi et al, "Nerve Growth Factor . . . ", pp. 3232-3245.
J. Neuroscience, vol. 5, No. 10, issued Oct. 1985, Kessler, "Parasympathetic, Sympathetic and Sensory Interactions . . . ", pp. 2719-2725.
PNAS USA, vol. 85, issued Apr. 1988, Lipton et al, "Acidic Fibroblast growth factor . . . ", pp. 2388-2392.
Nature, vol. 360, issued 24/31 Dec. 1992, Sendtner et al, "Brain-derived neurotrophic factor prevents . . . ", pp. 757-758.
Levi-Montalcini, "The Nerve Growth Factor 35 Years Later" Science (1987) 237:1154-1162.
Barde et al., "Purification of a New Neurotrophic Factor from Mammalian Brain" EMBO Journal (1982) 1:549-553.
Gaspodarowicz et al., "Isolation of Brain Fibroblast Growth Factor by Heparin-Sepharose Affinity Chromatography" Proc. Natl. Acad. Sci. USA (1984) 81:6963-6967.
Barbin et al., "Purification of the Chick Eye Ciliary Neuronotrophic Factor" Jour. of Neurochemistry (1984) 43:1468-1478.
Weber et al., "Molecular Properties of a Cholinergic Differentiation Factor from Muscle-Conditioned Medium" Jour. of Neurochemistry (1985) 45:1541-1547.
Fukada, "Purification and Partial Characterization of a Cholinergic Neuronal Differentiation Factor" Proc. Nat. Acad. Sci. USA (1985) 82:8795-8799.
Manthorpe et al., "An Automated Colorimetric Microassay for Neuronotrophic Factors" Dev. Brain Research (1986) 25:191-198.
Wallace et al., "Characterization of Choline Acetyltransferase-Sustaining and Survival-Promoting Activities for Parasymphathetic Neurons in Pig Lung" Brain Research (1986) 375:92-101.
Gurney et al., "Molecular Cloning and Expression of Neuroleukin, A Neurotrophic Factor for Spinal and Sensory Neurons" Science (1986) 234:566-574.
Watters et al., "Purification of a Ciliary Factor from Bovine Heart" Jour. of Neurochemistry (1987) 49:705-713.
Unsicker et al., "Astroglial and Fibroblast Growth Factors Have Neurotrophic Functions for Cultured Peripheral and Central Nervous System Neurons" Proc. Natl. Acad. Sci. USA (1987) 84:5459-5463.
Wallace et al., "Partial Purification of a Parasympathetic Neurotrophic Factor in Pig Lung" Brain Research (1987) 411:351-363.
Dal Toso et al., "Development and Survival of Neurons in Dissociated Fetal Mesencephalic Serum-Free Cell Cultures . . . " The Jour. of Neuroscience (1988) 8:733-745.
McManaman et al., "Purification of a Skeletal Muscle Polypeptide which Stimulates Choline Acetyltransferase Activity in Cultured Spinal Cord Neurons" The Jour. of Bio. Chemistry (1988) 263:5890-5897.
Anderson et al., "Basic Fibroblast Growth Factor Prevents Death of Lesioned Cholinergic Neurons In Vivo" Nature (1988) 332:360-361.
Angeletti et al., "Subunit Structure and Amino Acid Composition of Mouse Submaxillary Gland Nerve Growth Factor", Biochemistry (1971) 10:463-469.
Lin et al., "Purification, Cloning and Expression of Ciliary Neurotrophic Factor (CNTF)", Research Articles (1989), pp. 1023-2025.
Collins, "Electrophoretic Similarity of the Ciliary Ganglion Survival Factors from Different Tissues and Species", Dev. Biology (1985) 109:255-258.
Rudge et al., "An Examination of Ciliary Neuronotrophic Factors from Avian and Rodent Tissue Extracts using a Blot and Culture Technique", Dev. Brain Research (1987) 32:103-110.
Chemical Abstracts (1988) 109:67650z.
Hoffman, "Ciliary Neuronotrophic Factor Stimulates Choline acct,1-trasferase Activity in Cultured Chicken Retina Neurons", J. Neurochem. (1988) 51 (1):109-113.
Williams et al., "Continuous Infusion of Nerve Growth Factor Prevents Basal Forebrain Neuronal Death After Fimbria Fornix Transection", Proc. Natl. Acad. Sci. USA (1986) 83:9231-9235.
Lin et al., "Isolation and Characterization of Ciliary Neurotrophic Factor from Rabbit Sciatic Nerves", J. Biol. Chem. (1990) 265:8942-8947.
Rich et al., "Nerve Growth Factor Enhances Regeneration through Silicone Chambers", Exp. Neurol. (1989) 105:162-170.
Levi-Montalcini and Angeletti, "Nerve Growth Factor" Physicological Review (1968) 48:534-569.
Goodman and Gillman "Drugs Acting at Synaptic and Neuroeffector Junctional Sites", The Pharmacological Basis of Therapeutics, 7th ed. MacMillian Pub., New York, Chap. 4-11, pp. 66-235.
Wallace and Johnson, "Characterization of Choline Acetyltransferase-sustaining and Survival-promoting Activities . . . ", Brain Research (1986) 375:92-101.
Wallace and Johnson, "Partial Purification of a Parasympathetic Neurotrophic Factor in Pig Lung", Brain Research (1987) 441:351-363.
Lin et al., "Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)", Science (1989) 246:1023-1025.
Pinol-Roma et al., "A Novel Heterogenous Nuclear RNP Protein with a Unique Distribution on Nascent Transcripts", J. of Cellular Biology (1989) 109:2575-2587.
U.S. Pat. application Ser. No. 07/597,419 (Wallace et al.).
Science, vol. 251, issued 29 Mar. 1991, Oppenheim et al, "Control of Embryonic Motoneuron Survival In Vivo . . . ", pp. 1616-1618.

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