Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-12-15
1997-09-09
Allen, Marianne P.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, 530395, 530399, C07K 14435, C07K 14475
Patent
active
056658621
ABSTRACT:
The invention pertains to isolated neurotrophic factors, designated as ARIA, which are able to induce the formation of ion channels in a surface membrane of a cell. The amino acid sequence of the neurotrophic factors includes an EGF-like domain, and a second amino acid sequence encoded by at least a portion of an exon of the neurotrophic factor gene normally expressed in a neuronal cell, especially a nerve cell. The neurotrophic factor is distinct from, and essentially unrelated to, the chicken prion-like protein previously identified.
REFERENCES:
patent: 5237056 (1993-08-01), Fischbach
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Corfas Gabriel
Falls Douglas L.
Fischbach Gerald D.
Rosen Kenneth M.
Allen Marianne P.
President and Fellows of Harvard College
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