Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-05-21
2000-08-01
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
560 41, 562459, 562463, 562568, 564209, 514354, 514449, 514538, 514549, 514550, 546226, 546194, 5462791, 548533, A61K 31166, C07C22510, C07C 59347
Patent
active
060967625
ABSTRACT:
The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel .alpha.,.alpha.-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
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Dasgupta Bireshwar
Dubowchik Gene M.
Vrudhula Vivekananda M.
Vyas Dolatrai M.
Bristol--Myers Squibb Company
DuBoff Samuel J.
McKane Joseph
Wright Sonya N
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