Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Patent
1997-12-16
2000-01-11
Saunders, David
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
4241301, 4241521, 4241721, 424810, 5303879, 530868, A61K 39395, A61K 3900, C07K 1624
Patent
active
060132574
ABSTRACT:
The present invention relates to a method for the treatment of multiple sclerosis comprising administering to a patient an antibody which binds to neurotactin. Neurotactin is a membrane-anchored chemokine which is highly expressed in normal mammalian brain.
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Pan et al., "Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation" Nature 387:611-617, 1997.
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Santiago et al., "Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases" EMBO Journal 9:3593-3601, 1990.
Brocke, S et al. Experimental autoimmune encephalomyelitis in the mouse. in: Autoimmune Disease Models: A Guidebook. Cohen and Miller, eds. Academic Press, San Diego, CA. pp. 1-14, 1994.
Swanborg, RH. Clin. Immunol. Immunopath. 77(1):4-13, Oct. 1995.
Millennium BioTherapeutics, Inc.
Saunders David
VanderVegt F. Pierre
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