Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-12-07
2000-08-22
Jones, Dwayne C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A01N 4358, A01N 3150
Patent
active
061072966
ABSTRACT:
A class of substituted 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives as shown in Formula I, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 6-position, are selective ligands for GABA.sub.A receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit therof, and are accordingly of benefit in the treatment and/or prevention of neurodegeneration arising from cerebral ischemia. ##STR1##
REFERENCES:
patent: 4112095 (1978-09-01), Allen, Jr. et al.
patent: 4117130 (1978-09-01), Allen, Jr. et al.
patent: 4230705 (1980-10-01), Allen, Jr. et al.
patent: 4260755 (1981-04-01), Moran et al.
patent: 4260756 (1981-04-01), Moran et al.
patent: 4654343 (1987-03-01), Albright et al.
patent: 4788186 (1988-11-01), Occelli et al.
Hall, E. D. et al, "Neuroprotective Properties of the Benzodiazepine Receptor, Partial Agonist PNU-101017 in the Gerbil Forebrain Ischemia Model," Journ. of Cerebral Blood Flow and Metabolism, vol. 17, pp. 875-883 (1997).
Jones Dwayne C.
Lee Shu M.
Merck Sharp & Dohme Ltd.
Rose David L.
LandOfFree
Neuroprotective use of triazolo-pyridazine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Neuroprotective use of triazolo-pyridazine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neuroprotective use of triazolo-pyridazine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-581334