Neuroprotective drug

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C435S325000, C514S299000, C930S120000

Reexamination Certificate

active

06849597

ABSTRACT:
An agent for prevention or treatment of diseases involving degeneration or death of nerve cells, characterized by containing a growth hormone secretion promoting substance as an active ingredient, is provided.

REFERENCES:
patent: WO 9724369 (1997-07-01), None
patent: WO 9741878 (1997-11-01), None
patent: WO 9909991 (1999-03-01), None
patent: WO 0048623 (2000-08-01), None
C.Y. Bowers. Cell. Mol. Life Sci. 54: 1316-1329 (1998).
Scheepens A., et al., Alterations in the neural growth hormone axis following hypoxic-ischemic brain injury, (1999)Molecular Brain Research, 68: 88-100.
De Gennaro Colonna V., et al., Cardiac ischemia and impairment of vascular endothelium function in hearts from growth hormone-deficient rats: protection by hexarelin, (1997)European J. Pharm., 334: 201-207.
Smith, R.G., et al., A new orphan receptor involved in pulsatile growth hormone release, (1999)Trends Endocrinol. Metab., 10 (4): 128-135.
Kojima, M., et al., Ghrelin is a growth-hormone-releasing acylated peptide from stomach, (1999)Nature, 402 (6762): 656-660.
Sonntag, W.E., et al., Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1, (1997)Enodcrinology, 138 (8): 3515-20.

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