Neuroprotective composition and uses thereof

Details Neuroprotective composition and uses thereof Neuroprotective composition and uses thereof

2005-02-22

2005-02-22

Henley, III, Raymond J. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S557000, C514S558000, C514S725000, C514S763000

Reexamination Certificate

active

06858646

ABSTRACT:
A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

REFERENCES:
patent: 5395822 (1995-03-01), Izumi et al.
patent: 5652274 (1997-07-01), Martin
patent: 34 42 725 (1996-05-01), None
M.S. Gokhale et al. “A Mixture of Antioxidants and Fatty Acids Improves the Viability of Cultured Rat Hepatocytes Untreated with Doxorubicin”, XP-000995528, Toxicology in Vitro (1997) 753-759.
Alain Martin, “The Use of Antioxidants in Healing”, XP 000578697, Dermatol Surg 1996;22:146-160.

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