Neuroprotective bicyclic compounds and methods for their use

Details Neuroprotective bicyclic compounds and methods for their use Neuroprotective bicyclic compounds and methods for their use

2004-08-31

2011-11-29

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S282000

Reexamination Certificate

active

08067425

ABSTRACT:
Embodiments of this invention provide novel cyclic compounds structurally related to diketopiperazines and methods for their therapeutic use. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.

REFERENCES:
patent: 6147051 (2000-11-01), Watanabe et al.
patent: WO 99/40931 (1999-08-01), None
patent: WO 03/039487 (2003-05-01), None
patent: WO 03/041655 (2003-05-01), None
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 and 365.
ISR and IPER of PCT/US04/028308, Aug. 31, 2004, Neuren Pharmaceuticals.
Prakash, K.R.C., et al., “Synthesis and Biological Activity of Novel Neuroprotective Diketopiperazines”, Biorganic & Medicinal Chemistry, 2002 Elsevier Science Ltd.
Office Action dated Mar. 11, 2009 in U.S. Appl. No. 11/399,974.
IDS in U.S. Appl. No. 11/399,974 dated May 5, 2009, citing International Preliminary Report dated Apr. 23, 2009 in PCT/US2007/021744.
Reply to Office Action dated Jun. 16, 2009 in U.S. Appl. No. 11/399,974.
Office Action dated Sep. 25, 2009 in U.S. Appl. No. 11/399,974 citing.
Mann, et al., “Dopaminergic neurotransmitter systems in Alzheimer's disease and in Down's syndrome at middle age”, Journal of Neurology, Neurosurgery and Psychiatry 1987; 50:341-344.
Zarkovic, “4-Hydroxynonenal and neurodegenerative diseases”, Molecular Aspects of Medicine 24 (2003) 293-303.
Kostic, “Midbrain Dopaminergic Neuronal Degeneration in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis”, American Neurological Association 1997, 497-504.
Guttman, Mark, “Current concepts in the diagnosis and management of Parkinson's disease”, Canadian Medical Association 2003, 293-301.
Strategy for the Synthesis of Non-Proteinogenic Dipeptides, Liebigs Ann.Chem. 1988, 1025-1031; VCH Verlagsgesellachaft mbH, D-6940 Weinheim, 1988.
Cerebral Blood Flow & Metabolism, 23:342-354, 2003, The International Society for Cerebral Blood Flow and Metabolism, Lippincott Williams & Wilkins, Inc., Philadelphia.

Affiliated with

Also associated with

Rating

Neuroprotective bicyclic compounds and methods for their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neuroprotective bicyclic compounds and methods for their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neuroprotective bicyclic compounds and methods for their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4258098