Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2006-07-11
2006-07-11
Kemmerer, Elizabeth (Department: 1647)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C424S184100, C514S002600, C514S012200, C530S381000
Reexamination Certificate
active
07074402
ABSTRACT:
The present invention provides methods for treating subjects having or at risk of having a neuropathological disorder or brain inflammatory diseases with and without vascular involvement, and systemic inflammatory vascular disease by administering a therapeutically effective amount of Activated Protein C (APC) to the subject. Brain disorders and brain inflammatory vascular diseases that can be treated by the invention method include all neurodegenerative diseases with different types of neuronal dysfunction, including stroke, Alzheimer's disease, Parkinson's disease, Huntington disease, neuroimmunological disorders such as multiple scelrosis and Gullian-Barre, encephalitis, meningitis, as well as other peripheral vascular diseases, such as diabetes, hypertension, artheriosclerosis. Also included are methods of treatment using APC in combination with a co-factor, such as Protein S.
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Griffin John H.
Zlokovic Berislav Y.
Bunner Bridget E.
DLA Piper Rudnick Gray Cary US LLP
Kemmerer Elizabeth
The Scripps Research Institute
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