Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-31
2006-10-31
Aulakh, Charanjit S. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S113000, C548S305100, C548S455000, C514S394000, C514S415000
Reexamination Certificate
active
07129250
ABSTRACT:
This invention features ring-substituted pyrrolo-β-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas I–III, which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.
REFERENCES:
patent: 4877776 (1989-10-01), Murakata et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5057614 (1991-10-01), Davis et al.
patent: 5405864 (1995-04-01), Broka
patent: 5621101 (1997-04-01), Lewis et al.
patent: 5741808 (1998-04-01), Lewis et al.
patent: 5756494 (1998-05-01), Lewis et al.
patent: 5859261 (1999-01-01), Faul et al.
patent: 5883114 (1999-03-01), Kleinschroth et al.
patent: 5919912 (1999-07-01), Korneluk et al.
patent: 5919946 (1999-07-01), Faul et al.
patent: 6013646 (2000-01-01), Roder et al.
patent: 6020127 (2000-02-01), MacKenzie et al.
patent: 6037475 (2000-03-01), Faul et al.
patent: 40 05 970 (1991-08-01), None
patent: 0 328 026 (1989-08-01), None
patent: 0 397 060 (1990-11-01), None
patent: 0 540 956 (1993-05-01), None
patent: 0 643 966 (1995-03-01), None
patent: WO 94/02488 (1994-02-01), None
patent: WO 94/27982 (1994-12-01), None
patent: WO 95/07911 (1995-03-01), None
patent: WO 96/31515 (1996-10-01), None
patent: WO 97/34890 (1997-09-01), None
patent: WO 97/46565 (1997-12-01), None
patent: WO 97/49406 (1997-12-01), None
patent: WO 98/04551 (1998-02-01), None
patent: WO 99/42100 (1999-08-01), None
patent: WO 99/47518 (1999-09-01), None
patent: WO 99/47522 (1999-09-01), None
patent: WO 01/87887 (2001-11-01), None
Kitada, S. et al, “Blood”, 2000, 96,393.
Iqbal, K. et al., FEBS Lett., 1994, 349, 104.
Garver, T.D. et al., J. Neurosci. Res., 1996, 44, 12.
Kaneko, et al., J. Med. Chem., 1997, 40, 1863.
Maroney, A.C. et al., J. Neurosci. 1998, 18, 104.
Sancelme, et al., J. Antibiotics, 1994, 47, 792.
Hachisu et al., Life Sciences, 1989, 44, 1351.
Bit et al., J. Med. Chem., 1993, 36, 21.
Bergman et al., Tetrahedron Lett., 1987, 28, 4441.
Faul, M.M. et al., Tetrahedron Lett., 1999, 40, 1109.
Bradshaw, D. et al., Agents and Actions, 1993, 38, 137.
Knusel, B. & Hefti, F.J., Neurochem., 1992, 59, 1987.
Xu, D.G. et al., Nature Medicine, 1997, 3, 997.
Uzawa, et al., Cancer Genet Cytogenet, 1998, 11, 125.
Chan, S.L., Mattson, M.P., J. Neurosci. Res., 1999, 58, 167.
Kanfer, J.N. et al., Neurochem Res., 1999, 24, 1621.
Suzuki, A. et al., Exp. Cel. Res., 1997, 233, 41.
Gribble, G. W. et al., Studies in Natural Products Chemistry, 1993, 12, pp. 365-409.
Wood, J. L. et al., J. Am. Chem. Soc., 1997, 119, pp. 9641-9651.
Link et al., J. Am. Chem. Soc., 1996, 118, pp. 2825-2842.
Bergman, J. et al., Tetrahedron, 55, 1999, pp. 2363-2370.
Janosik et al., Tetrahedron, 55, 1999, pp. 2371-2380.
Nakanishi, J. Antibiotics, 1986, 39, pp. 1066-1071.
Toledo and Lydon, Structure, 1997, 5, No. 12, pp. 1551-1556.
Davis, P.D., et al., “Inhibitors of Protein Kinase C.I. 2,3-Bisarylmaleimides”, Journal of Medicinal Chemistry, vol. 35, No. 1, Jan. 10, 1992, pp. 177-184, XP002028954.
Davis, P.D., et al., “A Mild Conversion of Maleic Anhydrides into Meleimides” Tetrahedron Letters, vol. 31, No. 36, 1990, pp. 5201-5204, XP001021319.
Fallis Alexander Graham
Gillard John W.
Jaquith James B.
Laurent Alain
Aegera Therapeutics Inc.
Aulakh Charanjit S.
Borden Ladner Gervais LLP
Silver Gail C.
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