Neuroprotective agents

Details Neuroprotective agents Neuroprotective agents

2006-04-11

2006-04-11

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S331000, C514S020800, C562S560000, C562S562000

Reexamination Certificate

active

07026297

ABSTRACT:
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Rarepresents alkylene; Rband Rceach represents alkylene, the total number of carbon atoms in said straight chains of Rband Rcbeing 7); R2and R3each represents hydrogen, or a group of formula R, RCO—, ROCO—, or RNHCO—, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R1represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.

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