Neuropeptide antagonists

Details Neuropeptide antagonists Neuropeptide antagonists

1993-11-02

1995-07-18

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530329, 530314, 530315, A61K 3808, A61K 3811, A61K 3816, C07K 1100

Patent

active

054341329

ABSTRACT:
Oligopeptides have been found that antagonist cell proliferation stimulated not only by bombesin-like peptides but also other neuropeptides e.g. vasopressin and bradykinin. These oligopeptides block a broad family of mitogenic neuropeptides that bind to receptors that use the inositol signalling pathway and one such receptor has been identified. These oligopeptides are of particular interest in relation to small cell lung cancer.

REFERENCES:
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Woll et al (1988) PNAS 85:1859-1863.
Kris et al., J. Biol. Chem. (1987) 262(23):11215-11220.
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Fischer et al., J. Biol. Chem. (1988) 263(6):2808-2816.
Sundan, Biol. Abstracts/RRM (No. 35054560).
Sinnet-Smith et al., Chem. Abstracts (1989) 110(11):124.

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