Neuropathy remedies

Details Neuropathy remedies Neuropathy remedies

2005-04-26

2005-04-26

Killos, Paul J. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S569000

Reexamination Certificate

active

06884819

ABSTRACT:
The present invention provides a neurodegenerative disease therapeutic agent containing as its active ingredient a (15R)-isocarbacycline derivative indicated by the following formula [I] or a 15-deoxy-isocarbacycline derivative indicated by the following formula [III]:(wherein, R1represents a C1-C6alkylene group, and R2represents a hydrogen atom, a C1-C7, alkyl group or protective group); or,(wherein, R1and R2are the same as those defined in formula [I]).

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Masaaki Suzuki, et al., “Molecular Design of Prostaglandin Probes in Brain Research: High, Specific Binding to a Novel Prostacyclin Receptor in the Central Nervous system,” Bull. Chem. Soc. Japan, May 2000, vol. 73, pp. 1053-1070.
Masaaki Suzuki, et al. “15-Deoxy-16-(m-tolyl)-17, 18, 19, 20-tetranorisocarcarbacyclin: a simple TIC derivative with potent anti-apototic activity for neuronal cells”, Chemical Communications. (Cambridge), (1999), (4), pp. 307-308.
Masaaki Suzuki, et al. “Design of prostaglandins with high binding affinity and selectivity for an IP2 receptor in the central nervous system and their biological activity”, Tennen Yuki Kagobutsu Koen Yoshishu, (1998), 40th, pp. 145-150.
Masaaki Suzuki, et al., “(15R)-16-m-tolyl-17, 18, 19, 20- tetranorisocarcarbacyclin: A stable ligand with high binding affinity and selectivity for a prostacyclin receptor in the central nervous system”, Agnew, Chem. Int. Ed. Engl. 1996, 35, No. 3, pp. 334-336.

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