Neuronal stimulation using electrically conducting polymers

Surgery – Miscellaneous – Methods

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

607 50, 607116, 607117, A61B 1900

Patent

active

060951486

ABSTRACT:
Methods and support systems are provided for modifying the regeneration, differentiation, or function of cells. In one embodiment, electrically conducting biocompatible polymers may be used alone or in combination with a polymeric support for in vitro nerve cell regeneration, or in vivo to aid in healing nervous tissue defects. The conductive polymers may implanted adjacent to or seeded with nerve cells. Voltage or current is applied to the polymer in a range which induces the desired effect on the cells while not damaging the cells. The methods and systems can be used in a variety of applications to enhance in vivo or in vitro growth or regeneration of nervous tissue.

REFERENCES:
patent: 3654933 (1972-04-01), Hagfors
patent: 4341221 (1982-07-01), Testerman
patent: 4779630 (1988-10-01), Scharnberg et al.
patent: 4919140 (1990-04-01), Borgens et al.
patent: 4983322 (1991-01-01), Elsenbaumer
patent: 5073114 (1991-12-01), Detsch
patent: 5130412 (1992-07-01), Wellinghoff et al.
patent: 5330520 (1994-07-01), Maddison et al.
Aebischer, et al., "Piezoelectric guidance channels enhance regeneration in the mouse sciatic nerve after axotomy," Brain Res. 436(1):165-168 (1987).
Andreatta, et al., "Processing of Conductive Polyaniline-UHMW Polyethylene Blends from Solutions in Non-Polar Solvents," Synth. Met. 55(2 and 3):1017-1022 (1993).
Armes, "Optimum Reaction Conditions For the Polymerization of Pyrrole by Iron(III) Chloride in Aequeous Solution," Synth. Met. 20(3):365-371 (1987).
Bredas, et al., eds. Conjugated Polymeric Materials: Opportunities in Electronics, Optoelectronics, and Molecular Engineering, (Kluwer Academic Publisher, Dordrecht, 1991) (Table of Contents only).
Cao, et al., "Magnetic susceptibility of polyaniline in solution in non-polar organic solvents and in polyblends in poly(methyl methacrylate)," Synth. Met. 52:193-200 (1992).
Cao, et al., "Counter-ion induced processibility of conducting polyaniline and of conducting polyblends of polyaniline in bulk polymers," Synth. Met. 48:91-97 (1992).
Couves, et al., "Polypyrrole as a Potentiometric Glucose Sensor," Synt. Met. 28:C761-C768 (1989).
Decher, et al., "Buildup of ultrathin multilayer films by self-assembly process: III. consecutively alternating absorption of anionic and cationic polyelectrolytes on charged surfaces," Thin Solid Films 210/211(1 and 2):831-835 (1992).
Diaz, et al., "Electrochemistry of Conducting Polypyrrole Films," J. Electroanal. Chem., 129:115-132 (1981).
Greene, et al., "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor," Proc. Natl. Acad. Sci., USA 73(7):2424-2428 (1976).
Hu, "RNA Synthesis in Peripheral Nerve in the Chick During Development," Can. J. Biochem. 49:320-327 (1971).
Jaffe, et al., "Neurites Grow Faster Towards the Cathode than the Anode in a Steady Field," J. Exp. Zool. 209:115-127 (1979).
Kanatzidis, "Conductive Polymers," Chem. Eng. News 68:36-54 (1990).
Kerns, et al., "Electrical Stimulation of Nerve Regenration in the Rat: The Early Effects Evaluated By a Vibrating Probe and Electron Microscopy," Neuroscience 40(1):93-107 (1991).
Langer, et al., "Selective Cell Transplantation Using Bioabsorbable Artificial Polymers as Matrices," J. Ped. Surg. 23(1):3-9 (1988).
Lavine, et al., "Current Concepts Review Electrical Stimulation of Repair of Bone," J. of Bone and Joint Surgery 69-A:625-630 (1987).
Liao, et al., "Polymeric Dopants for Polyaniline," PSME Preprints Abstract No. 162 ACS Meeting, Chicago, (Aug. 1993).
Luther, et al., "Changes in cell shape and actin distribution induced by constant electric fields," Nature 303(5912):61-64 (1983).
Malhotra, et al., "Polyaniline/Polymeric Acid Composite, a Novel Conducting Rubber," J. Appl. Polym. Sci. 40(5 and 6):1049-1052 (1990).
Miller, ed., Extended Linear Chain Compounds, vol. 1, (Plenum Press, New York, 1983) (Table of Contents only).
Miller, L.L., "Electrochemically Controlled Release of Drug Ions from Conducting Polymers," Mol. Cryst. Liq. Cryst. 160:297-301 (1988).
Miller, et al., "Poly(N-methylpyrrolylium) Poly(styrenesulfonate). A Conductive, Electrically Switchable Cation Exchanger That Cathodically Binds and Anodically Releases Dopamine," Macromolecules 20:1594-1597 (1987).
Minehan, et al., "Kinetics of DNA Binding to Polypyrrole," Polym. Mat. Sci. Eng., 64:341-342 (1991).
Myers, "Chemical Oxidative Polymerization as a Synthetic Route to Electrically Conducting Polypyrroles," J. Electron. Mater. 15:61-69 (1986).
Patel, et al., "Perturbation of the Direction of Neurite Growth by Pulsed and Focal Electric Fields," J. Neurosc. 4(12):2939-2947 (1984).
Politis, et al., "Mammalian Optic Nerve Regeneration Following the Application of Electric Fields," J. Trauma 28(11):1548-1552 (1988).
Prezyna, et al., "Interaction of Cationic Polypeptides and Electroactive Polypyrrole/Poly(styrenesulfonate) and Poly(N-methylpyrrole)/ Poly(styrenesulfonate) Films," Macromolecules 24(19):5283-5287 (1991).
Sadik, et al., "Pulsed amperometric detection of proteins using antibody containing conducting polymers," Analytica. Chimica. Acta. 279:209-212 (1993).
Shastri, "Evaluation of Polypyrrole Thin Films of Substratum for Mammalian Cell Culture," Disseration Abstracts International, vol. 56/09-B, p. 4911 (Rensselaer Polytechnic Institute, 1995) (Abstract).
Shibib, et al., "Polarization of Nerve Regeneration (Electrotaxis)," Surg. Neurol. 29(5):372-388 (1988).
Shinohar, et al., "Electrically stimulated rupture of cell membranes with a conducting polymer-coated electrode," Biolectrochemistry and Bioenergetics 22:23-35 (1989).
Sisken, et al., "Stimulation of rat sciatic nerve regeneration with pulsed electromagnetic fields," Brain. Res. 485(2):309-316 (1989).
Smith, et al., "Investigation of the Relationship Between Conductivity and Protein-Binding Properties of Polypyrrole," J. Appl. Polym. Sci. 43(2):399-403 (1991).
Street, Handbook of Conducting Polymers, vol. 1 (Skotheim, ed.) (Marcel Dekker, Inc., New York) (Table of Contents).
Street, "Polypyrrole From Powers to Plastics," Chapter 8, (Marcel Dekker, Inc., New York) (Table of Contents).
Street, et al., "Conducting Polymers: A Review of Recent Work," IBM J. Res. Develop. 25(1):51-57 (1981).
Trivedi, et al., "Investigations on the effect of 5-sulfosalicylic acid on the properties of polyaniline," Synth. Met. 58(3):309-324 (1993).
Umana, et al., "Protein-Modified Electrodes. The Glucose Oxidase/Polypyrrole System," Anal. Chem. 58:2979-2983 (1986).
Valentini, et al., "Electrically charged polymeric substrates enhance nerve fibre outgrowth in vitro," Biomaterials 13(3):183-190 (1992).
Valentini, et al., "Polymer electret guidance channels enhance peripheral nerve regeneration in mice," Brain. Res. 480(1/2):300-304 (1989).
Wallace, et al., "Preparation and Application of Conducting Polymers Containing Chemically Active Counterions for Analytical Purposes," J. Electroanal. Chem. 247(1 and 2):145-156 (1988).
Wong, et al., Electrically conducting polymers can noninvasively control the shape and growth of mammalian cells, Proc. Natl. Acad. Sci., USA. 91:3201-3204 (1994).
Yang, et al., Polymer Preprints, ACS Meeting, 34(1) (Denver, Mar. 1993) (List of Attendees).
Yang, et al., "Processable conductive composites of polyaniline/poly(alkyl methacrylate) prepared via an emulsion method," Synth. Met. 59(1):1-12 (1993).
Yaoita, et al., "Electrically Regulated Cellular Morphological and Cytoskeletal Changes On An Optically Transparent Electrode (With 1 Color Plate)", Exptl. Cell Biol. 57:43-51 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Neuronal stimulation using electrically conducting polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neuronal stimulation using electrically conducting polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neuronal stimulation using electrically conducting polymers will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-654181

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.