Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2011-05-24
2011-05-24
Weber, Jon P (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S032000, C435S375000
Reexamination Certificate
active
07947435
ABSTRACT:
The present invention relates to a neuronal regeneration material screening method using ex vivo models, more precisely a neuronal regeneration material screening method using an organotypic spinal cord slice culture. The neuronal regeneration material screening method using spinal cord slices of living bodies of the present invention can be effectively applied for the development of a novel therapeutics for neurodegenerative diseases, such as spinal cord injury.
REFERENCES:
Lee Y-S et al. “aFGF Promotes Axonal Growth in Rat Spinal Cord Organotypic Slice Co-Cultures”, Journal of Neurotrauma, 2002, vol. 19, No. 3, pp. 357-367.
Crockett D.P. et al. “Number of Oligodendrocyte Progenitors Recruited to the Lesioned Spinal Cord Is Modulated by the Levels of the Cell Cycle Regulatory Protein p27Kip-1”, GLIA, 2005, vol. 49, pp. 301-308, entire document (Published online, Oct. 7, 2004).
Cho K.J. et al. “Neurons Derived From Human Mesenchymal Stem Cells Show Synaptic Transmission and Can Be Induced to Produce the Neurotransmitter Substance P By Interleukin-1alpha”, Stem Cells, 2005; vol. 23, pp. 383-391.
U2: Ho T.W. et al. TGF beta trophic factors defferentially modulate motor axon outgrowth and protection from excitotoxicity, Experimental Neurology, 2000, vol. 161, pp. 664-675.
JHK Law
Kim Joseph H.
Seoul National University Industry Foundation
Singh Satyendra K
Weber Jon P
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