Neuronal progenitor cells and uses thereof

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 691, 4351723, 424 9321, C12N 500, C12N 1509, A61K 4800

Patent

active

057535051

ABSTRACT:
The present invention provides an isolated cellular composition comprising greater than about 90% mammalian, non tumor-derived, neuronal progenitor cells which express a neuron-specific marker and which can give rise to progeny which can differentiate into neuronal cells. Also provided are methods of treating neuronal disorders utilizing this cellular composition.

REFERENCES:
patent: 5082670 (1992-01-01), Gage et al.
patent: 5175103 (1992-12-01), Lee
patent: 5589376 (1996-12-01), Anderson et al.
Luskin, M.B., "Restricted Proliferation and Migration of Postnatally Generated Neurons Derived From the Forebrain Subventricular Zone" Neuron 11:173 (1993).
Reynolds & Weiss, "Generation of Neurons and Astrocytes From Isolated Cells of the Adult Mammalian Central Nervous System" Science 255:1707 (1992).
Cattaneo & McKay, "Proliferation and Differentiation of Neuronal Stem Cells Regulated By Nerve Growth Factor" Nature 347:762 (1990).
Frederiksen & McKay, "Proliferation and Differentiation of Rat Neuroepithelial Precursor Cells In Vivo" J. Neurosci. 8:1144 (1988).
Kirschenbaum et al., "In Vitro Neuronal Production and Differentiation By Precursor Cells Derived From the Adult Human Forebrain" Cerebral Cortex 4:576 (1994).
Kirschenbaum & Goldman, "Brain-Derived Neurotrophic Factor Promotes The Survival of Neurons Arising From the Adult Rat Forebrain Subependymal Zone" Proc. Natl. Acad. Sci., 92:210 (1995).
Brain/Mind, "Key Brain Neurons Show Odd Migration Pattern," Aug. (1993).
Lois & Alvarez-Buylla, "Proliferating Subventricular Zone Cells in the Adult Mammalian Forebrain Can Differentiate Into Neurons and Glia" Proc. Natl. Acad. Sci. U.S.A. 90:2074 (1993).
Gage et al., "Isolation, Characterization, and Use of Stem Cells From the CNS" Annu. Rev. Neurosci. 18:159 (1995).
Vaysse & Goldman, "A Clonal Analysis of Glial Lineages in Neonatal Forebrain Development In Vitro" Neuron 5:227 (1990).
Lubetzki et al., "Clonal Segregation of Oligodendrocytes and Astrocytes During In Vitro Differentiation of Glial Progenitor Cells" Glia 6:289 (1992).
Kilpatrick & Bartlett, "Cloning and Growth of Multipotential Neural Precursors: Requirements For Proliferation and Differentiation" Neuron 10:255 (1993).
Morshead et al., "Neural Stem Cells In the Adult Mammalian Forebrain: A Relatively Quiescent Subpopulation of Subependymal Cells" Neuron 13:1071 (1994).
Reynolds et al., "A Multipotent EGF-ResponsiveStriatal Embryonic Progenitor Cell Produces Neurons and Astrocytes" J. Neuroscience 12:4565 (1992).
Temple, S., "Division and Differentiation of Isolated CNB Blast Cells In Microculture" Nature340:471 (1989).
Vescovi et al., "bFGF Regulates the Proliferative Fate of Unipotent (Neuronal) and Bipotent (Neuronal/Astroglial) EGF-Generated CNS Progenitor Cells" Neuron 11:951 (1993).
Price et al. "Cell lineage in the rat crebral cortex: a study using retroviral-mediated gene transfer,"Development, vol. 104: 473-482, 1988.
Davis et al. "A self-renewing multipotential stem cell in embryonic rat cerebral cortex," Nature, vol. 372: 263-266, Nov. 17, 1994.
Gritti et al. "Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor," J. of Neuroscience, vol. 16, No. 3: 1091-1100, Feb. 1, 1996.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Neuronal progenitor cells and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neuronal progenitor cells and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neuronal progenitor cells and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1852264

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.