Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-12-06
2000-10-24
Ulm, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 691, 4352523, 4353201, 436501, 536 235, G01N 33566, C12N 1512
Patent
active
061365505
ABSTRACT:
The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding subunits alpha2, alpha3, alpha4, and alpha5, plus non-agonist binding subunits beta2, beta3 and beta4. Representative cDNA clones that contain the DNA sequences of the invention have been deposited with the American Type Culture Collection for patent purposes.
REFERENCES:
patent: 4518527 (1985-05-01), Numa
Mishina et al. "Expression of Functional Acetylcholine receptor . . . ". Nature 307:604-608, Feb. 1984.
Whiting et al. Proc. Natl. Acad. Sci. USA 84:595-599, Jan. 1987.
Boulter et al. "Isolation of a cDNA clone coding fpr a possible neural nicotinic acetylcholine receptor alpha-subunit", Nature 319:368-374, Jan. 1986.
Goldman et al. "Members of a Nicotine Acetylcholine receptor gene family . . . ". Cell 48:204-213, Mar. 1987.
Whiting et al. "Functional acetylcholine receptor in PC12 cells . . . ". Nature 327:515-518, Jun. 1987.
Whiting et al. "Affinity Labeling of Neuronal acetylcholine receptors . . . ". FEBS Letters 23(1):55-60, Feb. 1984.
Ballivet Marc Charles
Boulter James Richard
Connolly John Gerard
Deneris Evan Samuel
Duvoisin Robert Michael
Reiter, Esq. Stephen E.
The Salk Institute for Biological Studies
Ulm John
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