Neuronal-neonatal gene: neuronatin

Details Neuronal-neonatal gene: neuronatin Neuronal-neonatal gene: neuronatin

1996-02-15

1998-11-17

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435357, 435368, 4353201, 4352523, 536 231, 536 241, C12N 1585, C12N 1563, C12N 1511

Patent

active

058375350

ABSTRACT:
The present invention is an isolated and purified DNA sequence which encodes a vertebrate mRNA for a neuron specific protein, neuronatin. The mRNA is selectively expressed in brain tissue during rapid brain growth when there is a surge in neuronal proliferation and migration and is repressed in adult tissue. In the human, the genomic DNA is as set forth in SEQ ID No:6 and the cDNA has a nucleotide sequence as set forth in SEQ ID No:5, with the gene mapped to human chromosome 20q11.2-12. The deduced protein is a proteolipid that appears to have a role in ion channel regulation during brain development.

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