Neuronal growth factor galectin-1

Details Neuronal growth factor galectin-1 Neuronal growth factor galectin-1

2005-05-10

2005-05-10

Kemmerer, Elizabeth (Department: 1647)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C436S503000, C436S529000, C530S350000, C930S280000, C514S002600

Reexamination Certificate

active

06890531

ABSTRACT:
This invention relates to a remedy for neuropathy, such as nerve injury, nerve degeneration, and hypofunction upon nerve grafting, which contains as the active ingredient galectin-1 having an amino acid sequence represented by SEQ ID NO:1 or its derivative; a protein having the amino acid sequence represented by SEQ ID NO:1 or one having a homology of 90% or more at the amino acid level with the sequence of SEQ ID NO:1 and carrying a disulfide bond(s) at least between Cys at the 16-position (Cys 16) and Cys at the 88-position (Cys 88) among cystein residues at the 2-position (Cys 2), 16-position (Cys 16), 42-position (Cys 42), 60-position (Cys 60), 88-position (Cys 88) and 130-position (Cys 130); and a process for producing the galectin-1 or its derivative protein by using an affinity column having an antibody to the above protein.

REFERENCES:
patent: 5693760 (1997-12-01), Seilhammer et al.
patent: 0 337 799 (1989-10-01), None
patent: 9808535 (1998-03-01), None
Chrispeels and Raikhel, 1991, The Plant Cell, 3: 1-9.*
Hirabayashi, et al, 1993, Accession No CAA32938.*
Tracey et al., “Subunit Molecular Mass Assignment of 14,654 Da To The Soluble β-Galactoside-Binding Lectin From Bovine Heart Muscle And Demonstration Of Intramolecular Disulfide Bonding Associated With Oxidative Inactivation”,The Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology, Inc., vol. 267(15):10342-10347, (1992).
Barondes et al., “Galectins: A Family Of Animal β-Galactoside-Binding Lectins”,Cell, Cell Press, vol. 76:597-598, (1994).
Kasai et al., “Galectins: A Family Of Animal Lectins That Decipher Glycocodes”,J. Biochem., vol. 119(1):1-8, (1996).
Yamaoka et al., “Structural And Functional Characterization Of A Novel tumor-Derived Rat Galectin-1 Having Transforming Growth Factor (TGF) Activity: the Relationship Between Intramolecular Disulfide Bridges And TGF Activity”,J. Biochem., vol. 119:878-886, (1996).
Puche et al., “Role of Galectin-1 in the Developing Mouse Olfactory System”, Development Biology, Article No. 0257, 1996, pp. 274-287, vol. 179, Academic Press, Inc.
Clerch et al., “Sequence of a Full-Length cDNA for Rat Lung β-Galactoside-Binding Protein: Primary and Secondary Structure of the Lectin”, Biochemistry, 1988, pp. 692-699, vol. 27, American Chemical Society.
Bladier et al., “β-Galactoside Soluble Lectin From Human Brain: Complete Amino Acid Sequence”, Neurochemistry International, 1991, pp. 275-281, vol. 18, No. 2, Pergamon Press.
Horie et al., “Identification of Oxidized Galectin-1 as an Initial Repair Regulatory Factor after Axotomy in Peripheral Nerves”, Neuroscience Research, 2000, pp. 131-137, vol. 38, Elsevier Science Ireland Ltd and the Japan Neuroscience Society.

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