Neuronal exocytosis inhibiting peptides and cosmetic and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S013800, C514S014800, C530S300000, C530S334000, C530S344000, C435S069100, C435S007100, C424S009100

Reexamination Certificate

active

07015192

ABSTRACT:
The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain said peptide and optionally one or more peptides from the carboxyl end of SNAP-25. Said compositions are suitable for the treatment of facial wrinkles and asymmetry and pathological neuronal exocytosis-mediated pathological disorders and alterations.

REFERENCES:
patent: WO 97/34620 (1997-09-01), None
Fasshauer et al., Biochemistry 37, 10354-10362 (1998).
Gutierrez, L.M., et al., “A Peptide that Mimics the C-terminal Sequence of SNAP-25 Inhibits Secretary Vesicle Docking in Chromaffin Cells,” The Journal of Biological Chemistry, vol. 272, No. 5, Jan. 31, 1997, pp. 2634-2639, the whole document, also available online at http://www-jbc.standford.edu/jbc/.
Oyler, G.A. et al., “The identification of a Novel Synaptosomal-Associated Protein, SNAP-25, Differentially Expressed by Neuronal Subpopulations,” The Journal of Cell Biology, vol. 109, No. 6, Dec. 1989, pp. 3039-3052, the whole document.

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