Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1996-04-08
1998-06-16
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, C07K 14475
Patent
active
057672520
ABSTRACT:
A novel neuronal cell growth factor, neuronal-activity regulated pentraxin, Narp, is provided, as well as polynucleotides encoding Narp. Narp is useful for induction of dendritic neurite outgrowth as well as promotion of neuronal migration. Methods for treatment of subjects having a neuronal cell disorder, utilizing Narp of the invention, are also provided.
REFERENCES:
Reid et al. J. Biological Chemistry 269 (1994) 32615-32620.
Noland et al J. Biological Chemistry 269 (1994) 32607-32614.
Rudinger In "Peptide Hormones" (Jun. 1976) ed. J.A. Parsons, University Park Press, Baltimore, pp. 1-7.
Tsui et al., "Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity", Jln of Neuroscience (Apr. 15, 1996) 16(8): 2463-2478.
Tsui et al., "Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity.", Molecular Biology of the Cell (Nov. 1995) 6:214A.
Tsui et al., "Narp, a novel member of the pentraxin family of proteins that is synthesized, secreted and active as a monomeric molecule", Society for Neuroscience Abstracts (Nov. 1996) 22:299.
Goodman et al., "Long pentraxins: an emerging group of proteins with diverse functions", Cytokine & Growth Factor Reviews (1996) 7(2):191-202.
Omeis et al., "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal location", Genomics (1996) 36:543-545.
Hsu, Yung-Chih et al., "Human Neuronal Pentraxin II (NPTX2): Conservation, Genomic Structure and Chromosomal Localization", Genomics 28:220-227 (1995).
Tsui Cynthia
Worley Paul
Hayes Robert C.
Hutzell Paula K.
The Johns Hopkins University School of Medicine
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