Neuromuscular blocking agents and antagonists

Details Neuromuscular blocking agents and antagonists Neuromuscular blocking agents and antagonists

1976-05-28

1977-06-14

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424267, A61K 3144, A61K 31445

Patent

active

040298000

ABSTRACT:
It is disclosed that 2-(4'-pyridyl)-1,3-dioxolane methiodide and 2-(1'-methyl-4'-piperidyl)-1,3-dioxolane hydroiodide are neuromuscular blocking agents or neuromuscular blocking agent antagonists, depending upon the amount of the drug administered.
At doses of 10.sup.-.sup.6 to 10.sup.-.sup.4 gm./kg. of body weight, they antagonize or reverse the effects of neuromuscular blocking agents, such as d-tubocurarine and succinylcholine, produce post-drug repetitive activity (PDR), block post-tetanic potentiation (PTP), have no direct muscle effect and reverse the PTP suppression caused by d-tubocurarine and succinylcholine; and at doses of 10.sup.-.sup.3 to 10.sup.-.sup.2 gm./kg. of body weight they act as neuromuscular blocking agents.

REFERENCES:
pinson et al., Archives Internatienales de Pharmcodynomie et de Therapie, vol. 219, No. 1, Jan. 1976, pp. 52-63.

Affiliated with

Also associated with

Rating

Neuromuscular blocking agents and antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neuromuscular blocking agents and antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neuromuscular blocking agents and antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-10844