Neuromuscular blocking agents

Details Neuromuscular blocking agents Neuromuscular blocking agents

1992-07-10

1995-09-26

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 3147, C07D21724

Patent

active

054535107

ABSTRACT:
1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-veratrylisoquinolium) said, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacological properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockade, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockage), in comparison with the known mixture of geometrical and optical isomers.

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Knabe, "Chirale Wirksubstanzen", Deutche Apatheken Seitung, 116 Jahrg, No. 24, pp. 849-851, 1989.
Nehmer, "Jour. of Chromatography" vol. 457, 1988, pp. 127-135.

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