Neuromuscular blocking agents

Details Neuromuscular blocking agents Neuromuscular blocking agents

1995-03-28

1996-09-17

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21724

Patent

active

055569781

ABSTRACT:
1R-cis, 1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis-(1,2,3,4-tetrahydro-6,7-dimet hoxy-2-methyl-1-veratrylisoquinolinium) salt, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacological properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockade, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockade), in comparison with the known mixture of geometrical and optical isomers.

REFERENCES:
patent: 4179507 (1979-12-01), Stenlake et al.
patent: 4578467 (1986-03-01), Bonacchi et al.
patent: 5453510 (1995-09-01), Hill et al.
Translation of German Article: J. Knabe, "Chirale Wirksubstanzen" pp. 1-6, Duutche ApathekenSeitung, 116 Jahrg, No. 24, pp. 849-851, 1984.
W. B. Wastila, et al.; TPZZ/92/0037-00; pp. 1-21; Apr. 30, 1992, Burroughs Welcome Co., Confidential Document, Research Triangle Park, N.C.
W. B. Wastila, et al.; TPZZ/920032-00; pp. 1-10; Apr. 6, 1992, Burroughs Welcome Co., Research Triangle Park, N.C., Confidential Document.
W. B. Wastila, et al.; TPZZ/92/0036-00; pp. 1-12; Apr. 22, 1992, Burroughs Welcome Co., Research Triangle Park, N.C., Confidential Document.
S. Quessy, Ph.D, et al.; THIB/92/0005/01; pp. 1-40; Jan. 12, 1993, Burroughs Welcome Co., Research Triangle Park, N.C., Confidential Document.
W. Wastila et al.; TPZZ/92/0035-00; pp. 1-11; Apr. 13, 1992, Burroughs Welcome Co., Research Triangle Park, N.C., Confidential Document.
W. B. Wastila; TPZZ/92/0041-00; pp. 1-39; May 5, 1992, Burroughs Welcome Co., Research Triangle Park, N.C., Confidential Document.
Decl. of Martha Abou-Donia, Ph.D along with Exhibit A; Ref. 1. Tracrium Package Insert, Jun. 1994; Ref. 2. Lien CA et al. Anesth Analg.; vol. 78; 1 page; 1994: Ref. 3. Lien CA et al. The Card. Effects and Histamine Releasing Props. of 51W89; 34 pages, Mar. 1994.
Declaration of John J. Savarese M.D.; 21 pages, Jul. 1992.
Package insert of Burroughs Wellcome's prior art Nuromax.RTM. Doxacurium Chloride.RTM. (U.S. Patent 4,701,460), and Mivacron.RTM. Mivacurium Chloride.RTM. (U.S. Patent 4,761,418), Aug. 1992.
Recollection of William B. Wastila's discussion with Patent Examiner Mr. J. Turnipseed held on Aug. 3, 1993 relating to the neuromuscular blocking agent 51W89.
Journal of Chrom. vol. 435; pp. 425-433, 1988, Nehmer.
Corrected and modified declaration of W. B. Wastila, pp. 1-3, Aug. 1993.
Declaration of J. B. Stenlake; 13 pages, 1994.
Declaration of Dr. P. W. Taylor; 47 pages, 1992.
Wastik,"Neuromuscular Blocking Profiles . . . ," document # TPZZ/90/0042, Burroughs Wellcome Co, Research Triangle Park, N.C., Confidential Document, 1990.
Basta, "Modulation of Histamine . . .", Anaesthesiology, pp. 572-576, 1992.

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