Neurologically active compounds and compounds with multiple acti

Details Neurologically active compounds and compounds with multiple acti Neurologically active compounds and compounds with multiple acti

1995-06-06

1999-09-28

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514245, 514261, 514388, 514395, 514396, 514397, 544194, 544197, 544205, 544206, 544208, 544267, 544272, 544276, 544277, A61K 3152, C07D47310, C07D47306, C07D47308

Patent

active

059589337

ABSTRACT:
A method for treating a mammal having a damaged central nervous system, as the result of trauma or disease, for reestablishing previously destroyed neurological functions in a traumatized or diseased mammal, or for controlling spasticity and for providing protection from such injury to the central nervous system. The method comprises administering to the mammal at least one neurologically active compound comprising two groups, one group providing alpha-adrenergic agonist activity, specifically a guanidino group, and the second group providing agonist activity selected from the group consisting of beta-adrenergic agonist activity, serotinergic agonist activity, and GABA-ergic agonist activity (for example a methylated xanthine group, having beta-adrenergic agonist activity) as the primary therapeutic agent. The neurologically active compound is administered in a dosage amount and at a dosage rate sufficient to at least partially restore the lost neurological function or to control spasticity.

REFERENCES:
Tani et al, CA75: 36137n, 1971.
Rostyslaw, J. Org. Chem. 29(9), 2766-8, 1964.

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