Neuroleptic radioreceptor assay method and kit

Details Neuroleptic radioreceptor assay method and kit Neuroleptic radioreceptor assay method and kit

1977-10-26

1980-04-08

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 206569, 424 12, G01N 3316, A61K 4300, B65D 8132

Patent

active

041972880

ABSTRACT:
Method, composition of matter and kit for determining the concentration of neuroleptic drug(s) in an animal or human patient's body fluid e.g., blood serum, blood plasma, urine, saliva, spinal fluid, etc., which comprises combining the patient's body fluid with dopamine receptor material and radioactive dopamine receptor binder and then measuring the percent inhibition of binding of the radioactive binder by the drug in the patient's fluid. The kit for performing the above method includes dopamine receptor material and radioactive dopamine receptor binder.

REFERENCES:
Enna et al., Nature, vol. 263, No. 5575, Sep. 23, 1976, pp. 338-341.
Enna et al., J. of Neurochem., vol. 26, 1976, pp. 221-224.
Snyder et al., Psychopharmacology Comm., vol. 1, No. 6, 1975, pp. 663-673.
Creese et al., Life Sciences, vol. 17, 1975, pp. 993-1002.
Seeman et al., Nature, vol. 261, Jun. 24, 1976, pp. 717-719.
Garnett et al., Radiopharmaceuticals and Labeled Compounds, vol. 1, _IAEA, Viena, 1973, pp. 405-410.

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