Neuroleptic indole-3-carboxamide derivatives

Details Neuroleptic indole-3-carboxamide derivatives Neuroleptic indole-3-carboxamide derivatives

1984-12-07

1986-10-07

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540602, 514323, 514414, 546201, 548467, A61K 3155, C07D40112, C07D40312

Patent

active

046160094

ABSTRACT:
Indole-3-carboxamide derivatives of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, phenyl which may be optionally substituted by halogen on the benzene ring or phenyl-C.sub.1-4 alkyl which may be optionally substituted by halogen on the benzene ring; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen, halogen, C.sub.1-4 alkyl, hydroxy or C.sub.1-4 alkoxy; R.sup.4 is hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, allyl or benzyl which may be optionally substituted by halogen on the benzene ring or by methyl on the .alpha.-carbon; R.sup.5 is hydrogen or C.sub.1-4 alkyl; m is 0 or 1; and n is an integer of 1 to 3, are useful as neuroleptic and anxiolytic drugs, and for the prevention and treatment of psychosomatic disturbances.

REFERENCES:
patent: 3136770 (1964-06-01), Gray
patent: 3527761 (1970-09-01), Archibald et al.
patent: 4140691 (1979-02-01), Weston et al.
Archibald, J. L., et al., Journal of Medicinal Chemistry, vol. 14, No. 11, 1971, pp. 1054-1059.

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