Neurokinin A antagonists

Details Neurokinin A antagonists Neurokinin A antagonists

1996-12-13

1998-11-03

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 21, 514826, 530328, 530329, 530332, A61K 3800

Patent

active

058308636

ABSTRACT:
Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.

REFERENCES:
patent: 4242256 (1988-05-01), Sharpe et al.
patent: 4439360 (1984-03-01), Verdini
patent: 4609643 (1986-09-01), Szelke et al.
patent: 4638047 (1987-01-01), Szelke et al.
patent: 4665157 (1987-05-01), Wright et al.
patent: 4680283 (1987-07-01), Veber et al.
patent: 4742156 (1988-05-01), Wright et al.
patent: 5084555 (1992-01-01), Coy et al.
patent: 5236921 (1993-08-01), Emonds-Alt
patent: 5317020 (1994-05-01), Emonds-Alt
patent: 5521156 (1996-05-01), Owen et al.
Sandberg, et al., Proc. Eur. Pept. Symp., 18th 369-372 (1984).
Mazrahi, et al., Eur. J. Pharmacol. 118:1-2, 25-36 (1985).
Reifenrath, et al., J. Med. Chem. 23:985-90 (1980).
Gao, et al., J. Med. Chem. 33:39-44 (1990).
Steinman, J. Med. Chem. 16(12):1354-60 (1973).
Barnes, Lancet 242-244 (Feb. 1, 1986).
Payan, et al., Am. Rev. Respir. Dis 136:539-34 (1987).
Devillier, et al., Inflammatory Diseases, vol. 314(20):1323.
The Merck Manual of Diagnosis and Therapy, 11th edition, 1076-1078 (1966).
Rosell, Subs. P. Metab. Biol. Actions (Proc Symp) Mtg in 1984, 95-97 (1985).
Abu Shanab, et al., Biochem Soc. Trans. 17(4), 731-2 (1989).
Harbeson, et al., J. of Cellular Biochemistry Supplement 14C, p. 242, (CK305) 1990.
Snider, et al., Chemistry & Industry, Nov. 4, 1991.
Logan, et al., Annual Reports in Medicinal Chemistry 26, Chapter 5, p. 43.
Dion, et al., Life Sciences 41, 2269-2278 (1987).
McLean, et al., Biochemica Et Biophysica Acta, vol. 1024, 1-4 (1990).
Dutta, A.S.,Drugs of the Future, vol. 12(8), 781-792 (1987).
Coy, D.H., et al., The J. of Biol. Chem., vol. 263(11), 5056-5060 (1988).
Cowan, A., et al., Peptides in Health and Disease, Italy, 13-16 Oct. 1987. Trends in Pharm. Sci. 9(1):1-3, (Jan. 1988).
Regoli, Chem Abst 107:109366C (1987), Int.Congr.Ser.-Excerpta Med. 731, 85-95 (1987).
Regoli, et al., Chem Abst 107:1525q, (1987) (5th Annu. Wash.Spring Symp.Health Sci.J.), 501-11(1986).
Hashimoto, Chem Abst 107:211967m, (1987), Chem. Pharm.Bull. 35(8), 3442-6(1987).
Hashimoto, et al., Chem Abst 108:32646e, Jpn. J. Pharmacology, 45(4), 570-3 (1987).
Ewenson, et al., Chem Abst 106 102664u (1985),, Proc. 9th Am. Pept. Symp.,639-42 (1987).
Cox, et al., Chem Abst 94:31068y (1981), J.Chem.Soc., Chem. Commun. 17, 800-2 (1980).
Buck, et al., Neuroscience Abst. 14:144 (1988), 18th Ann.Meeting for the Soc.for Neuroscience, Nov. 12-18 (1988).
Buck, et al., Chem Abst 109(11):86429a (1988), Life Sci., 42(26), 2701-8 (1988).
Rovero, et al., Chem Abst 111(13):109167w, Peptides 10(3), 593-5 (1989).
Rovero, et al., Chem Abstr 111(9):71117q (1989), Neuropeptides 13(4), 263-70 (1989).
Hashimoto, et al., Chem.Abst 107:21 (1987) 237277n.
Drapeau, et al., Chem Abst 107(19) 168939q (1987), Neuropeptides 10(1), 43-54 (1987).
Osakada, et al, Chem Abst 104(17): 142380p, Eur.J.Phrmacol. 120(2), 201-8 (1986).
Drapeau, et al., Chem. Abst 111:9 (1988) 71105j.
Bristow, et al., Br. J. Pharmac 90:211-217 (1987).
Holladay et al., Tetrahedron Letters 24:41, 4401-04 (1983).
Sasaki et al., Peptides 8, 119-121 (1987).
TenBrink, et al., J. Org. Chem. 52, 418-422 (1987).
Buck et al., Science 226, 987-989 (1984).
Spatola et al., Tetrahedron 44(3):821-33 (1988).
Chorev, et al., Int. J. Peptide Protein Res. 21:258-68 (1983).
Gisin, Helvetica Chimica Acta 56(5): 1476-82 (1973).
Kaiser, et al., Short Communications 595-598 (1969).
Sandberg, et al., Proc. Eur. Pept. Symp., 18th 369-372 (1984).
Mazrahi, et al., Eur. J. Pharmacol. 118:1-2, 25-36 (1985).
Harbeson et al., Peptides: Chemistry, Structures & Biology, Proceedings of the 11th American Peptides Symposium, Jul. 9-14, 1989.
Reifenrath, et al., J. Med. Chem. 23:985-90 (1980).
Gao, et al., J. Med. Chem. 33:39-44 (1990).
Steinman, J. Med. Chem. 16(12): 1354-60 (1973).
Barnes, Lancet 242-244 (Feb. 1, 1986).
Payan, et al., Am. Rev. Respir. Dis 136:539-34 (1987).
Devillier, et al., Inflammatory Diseases, vol. 314(20): 1323.
Dubreuil, et al., Drug Design and Delivery 2, 49-54 (1987).
Aumelas, et al., Int. J. Peptide Protein Res. 30:596-604 (1987).
Rovero, et al., Peptides 11:619-20 (1990).
Martinez, et al., J. Med. Chem. 28:1874-79 (1985).
Sasaki, et al., J. Med. Chem. 30:1162-66 (1987).
Morensen and Boyd, Organic Chemistry, 3rd edition, Chapter 3, pp. 79-82 (1974).
The Merck Manual of Diagnosis and Therapy, 11th edition, 1076-1078 (1966).
Abu Shanab, et al., Biochem Soc. Trans. 17(4), 731-2 (1989).
Snider, et al., Chemistry & Industry, Nov. 4, 1991.
Logan, et al., Annual Reports in Medicinal Chemistry 26, Chapter 5, p. 43.
Dion, et al., Life Sciences 41, 2269-2278 (1987).
McLean, et al., Biochimica Et Biophysica Acta, vol. 1024, 1-4 (1990).
Swistok, et al., Tetrahedron Letters, vol. 30(8):5045-5048 (1989).

Affiliated with

Also associated with

Rating

Neurokinin A antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neurokinin A antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neurokinin A antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-689168